AGuIX ® from bench to bedside-Transfer of an ultrasmall theranostic gadolinium-based nanoparticle to clinical medicine

AGuIX are sub-5 nm nanoparticles made of a polysiloxane matrix and gadolinium chelates. This nanoparticle has been recently accepted in clinical trials in association with radiotherapy. This review will summarize the principal preclinical results that have led to first in man administration. No evid...

Full description

Saved in:
Bibliographic Details
Published in:British journal of radiology 2019, Vol.92 (1093), p.20180365
Main Authors: Lux, François, Tran, Vu Long, Thomas, Eloïse, Dufort, Sandrine, Rossetti, Fabien, Martini, Matteo, Truillet, Charles, Doussineau, Tristan, Bort, Guillaume, Denat, Franck, Boschetti, Frédéric, Angelovski, Goran, Detappe, Alexandre, Crémillieux, Yannick, Mignet, Nathalie, Doan, Bich-Thuy, Larrat, Benoit, Meriaux, Sébastien, Barbier, Emmanuel, Roux, Stéphane, Fries, Peter, Müller, Andreas, Abadjian, Marie-Caline, Anderson, Carolyn, Canet-Soulas, Emmanuelle, Bouziotis, Penelope, Barberi-Heyob, Muriel, Frochot, Céline, Verry, Camille, Balosso, Jacques, Evans, Michael, Sidi-Boumedine, Jacqueline, Janier, Marc, Butterworth, Karl, McMahon, Stephen, Prise, Kevin, Aloy, Marie-Thérèse, Ardail, Dominique, Rodriguez-Lafrasse, Claire, Porcel, Erika, Lacombe, Sandrine, Berbeco, Ross, Allouch, Awatef, Perfettini, Jean-Luc, Chargari, Cyrus, Deutsch, Eric, Le Duc, Géraldine, Tillement, Olivier
Format: Article
Language:English
Subjects:
Animals
Bioengineering
Brain Neoplasms - pathology
Brain Neoplasms - therapy
Cancer
Forecasting
Gadolinium - administration & dosage
Head and Neck Neoplasms - diagnosis
Head and Neck Neoplasms - therapy
Humans
Life Sciences
Melanoma - pathology
Melanoma - therapy
Mice
Nanoparticles - administration & dosage
Pharmaceutical sciences
Radiation-Sensitizing Agents - administration & dosage
Review
Theranostic Nanomedicine - methods
Theranostic Nanomedicine - trends
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:AGuIX are sub-5 nm nanoparticles made of a polysiloxane matrix and gadolinium chelates. This nanoparticle has been recently accepted in clinical trials in association with radiotherapy. This review will summarize the principal preclinical results that have led to first in man administration. No evidence of toxicity has been observed during regulatory toxicity tests on two animal species (rodents and monkeys). Biodistributions on different animal models have shown passive uptake in tumours due to enhanced permeability and retention effect combined with renal elimination of the nanoparticles after intravenous administration. High radiosensitizing effect has been observed with different types of irradiations and on a large number of cancer types (brain, lung, melanoma, head and neck…). The review concludes with the second generation of AGuIX nanoparticles and the first preliminary results on human.
ISSN:0007-1285
1748-880X
DOI:10.1259/bjr.20180365