Concise Review: The Endothelial Cell Extracellular Matrix Regulates Tissue Homeostasis and Repair

All tissues are surrounded by a mixture of noncellular matrix components, that not only provide physical and mechanical support to cells, but also mediate biochemical signaling between cells. The extracellular matrix (ECM) of endothelial cells, also known as the perivascular matrix, forms an organ s...

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Bibliographic Details
Published in:Stem cells translational medicine 2019-04, Vol.8 (4), p.375-382
Main Authors: Witjas, Franca M. R., van den Berg, Bernard M., van den Berg, Cathelijne W., Engelse, Marten A., Rabelink, Ton J.
Format: Article
Language:English
Subjects:
Angiogenesis
Animals
Biology
Bone marrow
Cell adhesion & migration
Cell adhesion molecules
Cell interactions
Chondroitin sulfate
Collagen
Endothelial cell
Endothelial cells
Endothelial Cells - cytology
Endothelial Cells - physiology
Endothelium
Epidermal growth factor
Extracellular matrix
Extracellular Matrix - physiology
Fibroblasts
Genotype & phenotype
Glycoproteins
Glycosaminoglycan
Heparan sulfate
Homeostasis
Homeostasis - physiology
Humans
Induced pluripotent stem cells
Kinases
Liver
Mammals
Medicine
Microvasculature
Proteins
Regenerative medicine
Regenerative Medicine - methods
Stem cells
Tissue engineering
Tissue Engineering - methods
Tissue Engineering and Regenerative Medicine
Tissue regeneration
Tissue Scaffolds
Vascular endothelial growth factor
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Summary:All tissues are surrounded by a mixture of noncellular matrix components, that not only provide physical and mechanical support to cells, but also mediate biochemical signaling between cells. The extracellular matrix (ECM) of endothelial cells, also known as the perivascular matrix, forms an organ specific vascular niche that orchestrates mechano‐, growth factor, and angiocrine signaling required for tissue homeostasis and organ repair. This concise review describes how this perivascular ECM functions as a signaling platform and how this knowledge can impact the field of regenerative medicine, for example, when designing artificial matrices or using decellularized scaffolds from organs. Stem Cells Translational Medicine 2019;8:375–382
ISSN:2157-6564
2157-6580
2157-6580
DOI:10.1002/sctm.18-0155