Stimuli-Responsive Electrodes Detect Oxidative Stress and Liver Injury

A digital point‐of‐care biosensor for measuring reactive oxygen species is presented based on novel reactive oxygen species responsive polymer‐based electrodes. The biosensor is able to detect a drug‐induced liver injury by monitoring the oxidative stress in the blood.

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Bibliographic Details
Published in:Advanced materials (Weinheim) 2015-02, Vol.27 (8), p.1433-1436
Main Authors: Aran, Kiana, Parades, Jacobo, Rafi, Mohammad, Yau, Jennifer F., Acharya, Abhinav P., Zibinsky, Mikhail, Liepmann, Dorian, Murthy, Niren
Format: Article
Language:English
Subjects:
Acetaminophen - adverse effects
Animals
Biosensing Techniques - instrumentation
Biosensors
Blood
Chemical and Drug Induced Liver Injury - blood
Chemical and Drug Induced Liver Injury - metabolism
Digital
Electrodes
Hydroxyl Radical - blood
Injuries
interdigitated microelectrodes
Liver
Mice
Monitoring
Oxidative Stress - drug effects
Polyethylene Glycols - chemistry
reactive oxygen species
Stresses
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Description
Summary:A digital point‐of‐care biosensor for measuring reactive oxygen species is presented based on novel reactive oxygen species responsive polymer‐based electrodes. The biosensor is able to detect a drug‐induced liver injury by monitoring the oxidative stress in the blood.
ISSN:0935-9648
1521-4095
1521-4095
DOI:10.1002/adma.201404562