Loading…
Use of computed tomography and radiation therapy planning software to develop a novel formula for body surface area calculation in dogs
Background Body surface area (BSA) can reflect metabolic rate that might normalize dosing of chemotherapeutics across widely variable weights within a species. The current BSA formula for dogs lacks height, length, and body condition. Hypothesis Computed tomography (CT) imaging will allow inclusion...
Saved in:
Published in: | Journal of veterinary internal medicine 2019-03, Vol.33 (2), p.792-799 |
---|---|
Main Authors: | , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Summary: | Background
Body surface area (BSA) can reflect metabolic rate that might normalize dosing of chemotherapeutics across widely variable weights within a species. The current BSA formula for dogs lacks height, length, and body condition.
Hypothesis
Computed tomography (CT) imaging will allow inclusion of morphometric variables in allometric modeling of BSA in dogs resulting in an improved formula for BSA estimation.
Animals
Forty‐eight dogs from 4 institutions with whole‐body CT images.
Methods
Retrospective and prospective case series. Body surface area was contoured using whole‐body CT scans and radiation therapy planning software. Body length and height were determined from CT images and also in 9 dogs by physical measurement. Nonlinear regression was used to model the BSA data sets using allometric equations. Goodness‐of‐fit criteria included average relative deviation, mean standard error, Akaike information criterion, and r2 (derived from the r‐value generated by regression models).
Results
Contoured BSA differed from the current formula by −9% to +19%. Nonlinear regression on untransformed data yielded BSA = 0.0134 × body weight [kg]∧0.4746 × length (cm)∧0.6393 as the best‐fit model. Heteroscedasticity (increasing morphometric variability with increasing BSA) was an important finding.
Conclusions and Clinical Importance
Computed tomography‐derived BSA was used to incorporate body length into a novel BSA formula. This formula can be applied prospectively to determine whether it correlates with adverse events attributed to chemotherapy. |
---|---|
ISSN: | 0891-6640 1939-1676 |
DOI: | 10.1111/jvim.15440 |