Assessment of breath volatile organic compounds in acute cardiorespiratory breathlessness: a protocol describing a prospective real-world observational study

IntroductionPatients presenting with acute undifferentiated breathlessness are commonly encountered in admissions units across the UK. Existing blood biomarkers have clinical utility in distinguishing patients with single organ pathologies but have poor discriminatory power in multifactorial present...

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Bibliographic Details
Published in:BMJ open 2019-03, Vol.9 (3), p.e025486
Main Authors: Ibrahim, Wadah, Wilde, Michael, Cordell, Rebecca, Salman, Dahlia, Ruszkiewicz, Dorota, Bryant, Luke, Richardson, Matthew, Free, Robert C, Zhao, Bo, Yousuf, Ahmed, White, Christobelle, Russell, Richard, Jones, Sheila, Patel, Bharti, Awal, Asia, Phillips, Rachael, Fowkes, Graham, McNally, Teresa, Foxon, Clare, Bhatt, Hetan, Peltrini, Rosa, Singapuri, Amisha, Hargadon, Beverley, Suzuki, Toru, Ng, Leong L, Gaillard, Erol, Beardsmore, Caroline, Ryanna, Kimuli, Pandya, Hitesh, Coates, Tim, Monks, Paul S, Greening, Neil, Brightling, Christopher E, Thomas, Paul, Siddiqui, Salman
Format: Article
Language:English
Subjects:
Acute Disease
Adult
Atmospheric pressure
Breath Tests
Cardiovascular Diseases - diagnosis
Chronic obstructive pulmonary disease
Data Collection
Diagnosis, Differential
Dyspnea
Dyspnea - diagnosis
Exhalation
Gas Chromatography-Mass Spectrometry
Humans
Ions
Multicenter Studies as Topic - methods
Observational studies
Observational Studies as Topic - methods
Prospective Studies
Respiratory Medicine
Respiratory Tract Diseases - diagnosis
Sample Size
Sputum
VOCs
Volatile organic compounds
Volatile Organic Compounds - analysis
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Summary:IntroductionPatients presenting with acute undifferentiated breathlessness are commonly encountered in admissions units across the UK. Existing blood biomarkers have clinical utility in distinguishing patients with single organ pathologies but have poor discriminatory power in multifactorial presentations. Evaluation of volatile organic compounds (VOCs) in exhaled breath offers the potential to develop biomarkers of disease states that underpin acute cardiorespiratory breathlessness, owing to their proximity to the cardiorespiratory system. To date, there has been no systematic evaluation of VOC in acute cardiorespiratory breathlessness. The proposed study will seek to use both offline and online VOC technologies to evaluate the predictive value of VOC in identifying common conditions that present with acute cardiorespiratory breathlessness.Methods and analysisA prospective real-world observational study carried out across three acute admissions units within Leicestershire. Participants with self-reported acute breathlessness, with a confirmed primary diagnosis of either acute heart failure, community-acquired pneumonia and acute exacerbation of asthma or chronic obstructive pulmonary disease will be recruited within 24 hours of admission. Additionally, school-age children admitted with severe asthma will be evaluated. All participants will undergo breath sampling on admission and on recovery following discharge. A range of online technologies including: proton transfer reaction mass spectrometry, gas chromatography ion mobility spectrometry, atmospheric pressure chemical ionisation-mass spectrometry and offline technologies including gas chromatography mass spectroscopy and comprehensive two-dimensional gas chromatography-mass spectrometry will be used for VOC discovery and replication. For offline technologies, a standardised CE-marked breath sampling device (ReCIVA) will be used. All recruited participants will be characterised using existing blood biomarkers including C reactive protein, brain-derived natriuretic peptide, troponin-I and blood eosinophil levels and further evaluated using a range of standardised questionnaires, lung function testing, sputum cell counts and other diagnostic tests pertinent to acute disease.Ethics and disseminationThe National Research Ethics Service Committee East Midlands has approved the study protocol (REC number: 16/LO/1747). Integrated Research Approval System (IRAS) 198921. Findings will be presented at academic co
ISSN:2044-6055
2044-6055
DOI:10.1136/bmjopen-2018-025486