Temporal evolution of cortical ensembles promoting remote memory retrieval

Memories of fearful events can last a lifetime. The prelimbic (PL) cortex, a subregion of prefrontal cortex, plays a critical role in fear memory retrieval over time. Most studies have focused on acquisition, consolidation, and retrieval of recent memories, but much less is known about the neural me...

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Bibliographic Details
Published in:Nature neuroscience 2019-03, Vol.22 (3), p.460-469
Main Authors: DeNardo, Laura A, Liu, Cindy D, Allen, William E, Adams, Eliza L, Friedmann, Drew, Fu, Lisa, Guenthner, Casey J, Tessier-Lavigne, Marc, Luo, Liqun
Format: Article
Language:English
Subjects:
Analysis
Animals
Brain
Cerebral Cortex - physiology
Comparative analysis
Conditioning, Classical
Cortex (temporal)
Criticism
Fear
Hippocampus (Brain)
Human-computer interaction
Integrases - metabolism
Labels
Learning
Learning - physiology
Memory, Long-Term - physiology
Mental Recall - physiology
Mice, Inbred C57BL
Mice, Transgenic
Neurons
Neurons - physiology
Prefrontal cortex
Prefrontal Cortex - physiology
Retrieval
Retrieval (Memory)
Tamoxifen - administration & dosage
Time dependence
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Summary:Memories of fearful events can last a lifetime. The prelimbic (PL) cortex, a subregion of prefrontal cortex, plays a critical role in fear memory retrieval over time. Most studies have focused on acquisition, consolidation, and retrieval of recent memories, but much less is known about the neural mechanisms of remote memory. Using a new knock-in mouse for activity-dependent genetic labeling (TRAP2), we demonstrate that neuronal ensembles in the PL cortex are dynamic. PL neurons TRAPed during later memory retrievals are more likely to be reactivated and make larger behavioral contributions to remote memory retrieval compared to those TRAPed during learning or early memory retrieval. PL activity during learning is required to initiate this time-dependent reorganization in PL ensembles underlying memory retrieval. Finally, while neurons TRAPed during earlier and later retrievals have similar broad projections throughout the brain, PL neurons TRAPed later have a stronger functional recruitment of cortical targets.
ISSN:1097-6256
1546-1726
DOI:10.1038/s41593-018-0318-7