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Translational Research Working Group Developmental Pathway for Immune Response Modifiers
The Translational Research Working Group (TRWG) was created as a national initiative to evaluate the current status of the investment of National Cancer Institute in translational research and envision its future. The Translational Research Working Group conceptualized translational research as a se...
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Published in: | Clinical cancer research 2008-09, Vol.14 (18), p.5692-5699 |
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Main Authors: | , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | The Translational Research Working Group (TRWG) was created as a national initiative to evaluate the current status of the
investment of National Cancer Institute in translational research and envision its future. The Translational Research Working
Group conceptualized translational research as a set of six developmental processes or pathways focused on various clinical
goals. One of those pathways describes the development of immune response modifiers such as vaccines and cytokines. A hallmark
of the Immune Response Modifier Developmental Pathway is the coordinated development of multiple components. The Immune Response
Modifier Pathway was conceived not as a comprehensive description of the corresponding real-world processes but rather as
a tool designed to facilitate movement of a candidate assay through the translational process to the point where it can be
handed off for definitive clinical testing. This paper discusses key challenges associated with the immune response modifier
agent development process in light of the pathway. |
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ISSN: | 1078-0432 1557-3265 |
DOI: | 10.1158/1078-0432.CCR-08-1266 |