High Dialysate Calcium Concentration is Associated with Worsening Left Ventricular Function

Dialysate calcium concentration (d[Ca]) might have a cardiovascular impact in patients on haemodialysis (HD) since a higher d[Ca] determines better hemodynamic tolerability. We have assessed the influence of d[Ca] on global longitudinal strain (GLS) by two-dimensional echocardiography using speckle-...

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Bibliographic Details
Published in:Scientific reports 2019-02, Vol.9 (1), p.2386-2386, Article 2386
Main Authors: Silva, V B, Macedo, T A, Braga, T M S, Silva, B C, Graciolli, F G, Dominguez, W V, Drager, L F, Moysés, R M, Elias, R M
Format: Article
Language:English
Subjects:
Blood pressure
C-reactive protein
Calcium
Calcium (blood)
Dialysate
Echocardiography
Heart
Hemodialysis
Hemoglobin
Hypertension
Kidney diseases
Mortality
Proteins
Transferrin
Ultrafiltration
Ultrasonic imaging
Ventricle
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Summary:Dialysate calcium concentration (d[Ca]) might have a cardiovascular impact in patients on haemodialysis (HD) since a higher d[Ca] determines better hemodynamic tolerability. We have assessed the influence of d[Ca] on global longitudinal strain (GLS) by two-dimensional echocardiography using speckle-tracking imaging before and in the last hour of HD. This is an observational crossover study using d[Ca] 1.75 mmol/L and 1.25 mmol/L. Ultrafiltration was the same between interventions; patients aged 44 ± 13 years (N = 19). The 1.75 mmol/L d[Ca] was associated with lighter drop of blood pressure. Post HD serum total calcium was higher with d[Ca] 1.75 than with 1.25 mmol/L (11.5 ± 0.8 vs. 9.1 ± 0.5 mg/dL, respectively, p 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-019-38887-y