Argon Mitigates Impaired Wound Healing Process and Enhances Wound Healing In Vitro and In Vivo

Diabetic foot ulcers are associated with significant morbidity and mortality, and current treatments are far from optimal. Chronic wounds in diabetes are characterised by impaired angiogenesis, leukocyte function, fibroblast proliferation, and keratinocyte migration and proliferation. : We tested th...

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Bibliographic Details
Published in:Theranostics 2019, Vol.9 (2), p.477-490
Main Authors: Ning, Jiaolin, Zhao, Hailin, Chen, Bin, Mi, Emma Zheling, Yang, Zhen, Qing, Wenhan, Lam, Kwok Wing Joyce, Yi, Bin, Chen, Qian, Gu, Jianteng, Ichim, Thomas, Bogin, Vladimir, Lu, Kaizhi, Ma, Daqing
Format: Article
Language:English
Subjects:
Animals
Argon - administration & dosage
Cells, Cultured
Diabetes Mellitus - chemically induced
Diabetic Foot - drug therapy
Diabetic Foot - pathology
Disease Models, Animal
Endothelial Cells - drug effects
Fibroblasts - drug effects
Keratinocytes - drug effects
Macrophages - drug effects
Mice
Neovascularization, Physiologic - drug effects
Research Paper
Treatment Outcome
Wound Healing - drug effects
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Summary:Diabetic foot ulcers are associated with significant morbidity and mortality, and current treatments are far from optimal. Chronic wounds in diabetes are characterised by impaired angiogenesis, leukocyte function, fibroblast proliferation, and keratinocyte migration and proliferation. : We tested the effect of exposure to argon gas on endothelial cell, fibroblast, macrophage and keratinocyte cell cultures and of a streptozotocin-induced diabetic mouse model. : Exposure to normobaric argon gas promotes multiple steps of the wound healing process. Argon accelerated angiogenesis, associated with upregulation of pro-angiogenic Angiopoietin-1 and vascular endothelial growth factor (VEGF) signalling and . Treatment with argon enhanced expression of transforming growth factor (TGF)-β, early recruitment of macrophages and keratinocyte proliferation. Argon had a pro-survival effect, inducing expression of cytoprotective mediators B-cell lymphoma 2 and heme oxygenase 1. Argon was able to accelerate wound closure in a diabetic mouse model. : Together these findings indicate that argon gas may be a promising candidate for clinical use in treatment of diabetic ulcers.
ISSN:1838-7640
1838-7640
DOI:10.7150/thno.29361