CT Hounsfield Unit Is a Good Predictor of Growth in Meningiomas

Predicting the growth rate of meningiomas is important in treatment planning. Although calcification may be an important sign of slow growth in meningiomas, the developmental process and its relation to the tumor growth pattern have not been elucidated. We retrospectively examined the location and d...

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Bibliographic Details
Published in:Neurologia medico-chirurgica 2019, Vol.59(2), pp.54-62
Main Authors: NAKASU, Satoshi, ONISHI, Takeshi, KITAHARA, Sawako, OOWAKI, Hisayuki, MATSUMURA, Ken-ichi
Format: Article
Language:eng ; jpn
Subjects:
Calcification
Computed tomography
CT scan
growth kinetics
Growth rate
Hounsfield units
meningioma
Multivariate analysis
Original
Tumors
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Summary:Predicting the growth rate of meningiomas is important in treatment planning. Although calcification may be an important sign of slow growth in meningiomas, the developmental process and its relation to the tumor growth pattern have not been elucidated. We retrospectively examined the location and degree of calcification in 150 meningiomas (131 asymptomatic tumors) using computed tomography (CT) scans and mean Hounsfield units (mHU). Tumor growth was evaluated using serial imaging studies wherein we calculated tumor doubling time (Td) and identified the growth curve pattern as exponential, intermediate, or decelerating. Tumors in women more frequently had calcification and showed higher mHU than those in men. The mHU was measured at least twice in 57 tumors. Tumors in women showed greater mHU increases than those in men. We found a significant correlation between Td and mHU (R = 0.49). Tumors in men and those in patients in the younger age group grew significantly faster. Multivariate analysis revealed that mHU was the only significant factor affecting Td (P
ISSN:0470-8105
1349-8029
DOI:10.2176/nmc.oa.2018-0209