Association between decreased serum TBIL concentration and immediate memory impairment in schizophrenia patients

Cognitive impairment is a core feature of schizophrenia (SCH). In addition to the toxic effect of Bilirubin (BIL), it has antioxidant properties that were associated with the psychopathology and cognitive impairment of psychiatric disorders. The aim of this study was to examine the correlation of se...

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Bibliographic Details
Published in:Scientific reports 2019-02, Vol.9 (1), p.1622, Article 1622
Main Authors: Yin, Xiao Li, Jia, Qiu Fang, Zhang, Guang Ya, Zhang, Jian Ping, Shirao, Tomoaki, Jiang, Cai Xia, Yin, Xu Yuan, Liu, Yan Song, Chen, Peng, Gu, Xiao Chu, Qian, Zheng Kang, Yin, Guang Zhong, Sen Xia, Hai, Hui, Li
Format: Article
Language:English
Subjects:
Antioxidants
Bilirubin
Cognitive ability
Memory
Mental disorders
Multiple regression analysis
Psychopathology
Schizophrenia
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Summary:Cognitive impairment is a core feature of schizophrenia (SCH). In addition to the toxic effect of Bilirubin (BIL), it has antioxidant properties that were associated with the psychopathology and cognitive impairment of psychiatric disorders. The aim of this study was to examine the correlation of serum total BIL (TBIL) concentration with cognitive impairment in SCH patients. We recruited 34 SCH patients and 119 healthy controls (HCs) in this case-control design. Cognition was assessed using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Serum TBIL concentration was measured using the immunoturbidimetric method. Serum TBIL concentration was significantly decreased in SCH patients compared to HCs after adjusting for age, gender, and education. Serum TBIL concentration in SCH patients was also positively correlated with the RBANS immediate memory score. Further stepwise multiple regression analysis confirmed the positive association between serum TBIL concentration and immediate memory score in SCH patients. Our findings supported that the decline in serum TBIL concentration was associated with the immediate memory impairment and psychopathology of SCH.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-018-38227-6