Citrate‐Based Fluorescent Biomaterials

Fluorescence imaging has emerged as a promising technique for monitoring and assessing various biologically relevant species in cells and organisms, driving the demand for effective fluorescent agents with good biocompatibility and high fluorescence performance. However, traditional fluorescent agen...

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Bibliographic Details
Published in:Advanced healthcare materials 2018-09, Vol.7 (18), p.e1800532-n/a
Main Authors: Shan, Dingying, Hsieh, Jer‐Tsong, Bai, Xiaochun, Yang, Jian
Format: Article
Language:English
Subjects:
Biocompatibility
Biocompatible Materials - chemistry
Biodegradability
Biodegradation
bioimaging
Biomaterials
Biomedical materials
Biomonitoring
carbon dots
Chemical compounds
Citrates - chemistry
Citric acid
Cost effectiveness
degradation
Fluorescence
Fluorophores
Innovations
Material properties
Optical Imaging - methods
Photobleaching
Photoluminescence
Polymers
Polymers - chemistry
Quantum dots
Quantum Dots - chemistry
R&D
Research & development
Toxicity
Wavelengths
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Summary:Fluorescence imaging has emerged as a promising technique for monitoring and assessing various biologically relevant species in cells and organisms, driving the demand for effective fluorescent agents with good biocompatibility and high fluorescence performance. However, traditional fluorescent agents, such as quantum dots (QDs) and organic dyes, either suffer from toxicity concerns or poor fluorescence performance (e.g., low photobleaching‐resistance). In this regard, citrate‐based fluorescent biomaterials, which are synthesized from the natural and biocompatible precursor of citric acid (CA), have become competitive alternatives for fluorescence imaging owing to their biocompatibility, cost effectiveness, straightforward synthetic routes, flexible designability, as well as strong fluorescence with adjustable excitation/emission wavelengths. Accordingly, numerous citrate‐based biomaterials, including carbon dots (CDs), biodegradable photoluminescent polymers (BPLPs), and small molecular fluorophores, have been developed and researched in the past few decades. This review discusses recent progress in the research and development of citrate‐based fluorescent materials with emphasis on their design and synthesis considerations, material properties, fluorescence properties and mechanisms, as well as biomedical applications. It is expected that this review will provide an insightful discussion on the citrate‐based fluorescent biomaterials, and lead to innovations for the next generation of fluorescent biomaterials and fluorescence‐based biomedical technology. Citrate‐based fluorescent biomaterials have become promising candidates for bioimaging owing to their biocompatibility, cost effectiveness, and excellent fluorescence properties. This review provides a comprehensive discussion of the synthesis strategies, material properties, fluorescence properties, and mechanisms, as well as biomedical applications of various citrate‐based fluorescent materials, including carbon dots (CDs), biodegradable photoluminescent polymers (BPLPs), and small molecular fluorophores.
ISSN:2192-2640
2192-2659
2192-2659
DOI:10.1002/adhm.201800532