Assessment of the toxic potential of graphene family nanomaterials

Graphene, a single-atom-thick carbon nanosheet, has attracted great interest as a promising nanomaterial for a variety of bioapplications because of its extraordinary properties. However, the potential for widespread human exposure raises safety concerns about graphene and its derivatives, referred...

Full description

Saved in:
Bibliographic Details
Published in:Yàowu shi͡p︡in fenxi 2014-03, Vol.22 (1), p.105-115
Main Authors: Guo, Xiaoqing, Mei, Nan
Format: Article
Language:English
Subjects:
Animal models
Animals
Biocompatibility
Biological products
Biomedical materials
Cancer
Carbon
Cytochrome
Cytotoxicity
Drug Delivery Systems
Drugs
Efficiency
Fabrication
Food
Food Packaging
Functionalization
Genotoxicity
Graphene
Graphene oxide
Graphite - chemistry
Humans
Mammalian cells
Nanomaterials
Nanostructures - chemistry
Nanostructures - toxicity
Nanotechnology
Physiology
Polyethylene glycol
Reduced graphene oxide
Researchers
Review
Standardization
Surface chemistry
Toxicity
Toxicology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Graphene, a single-atom-thick carbon nanosheet, has attracted great interest as a promising nanomaterial for a variety of bioapplications because of its extraordinary properties. However, the potential for widespread human exposure raises safety concerns about graphene and its derivatives, referred to as graphene-family nanomaterials. This review summarizes recent findings on the toxicological effects and the potential toxicity mechanisms of graphene-family nanomaterials in bacteria, mammalian cells, and animal models. Graphene, graphene oxide, and reduced graphene oxide elicit toxic effects both in vitro and in vivo, whereas surface modifications can significantly reduce their toxic interactions with living systems. Standardization of terminology and the fabrication methods of graphene-family nanomaterials are warranted for further investigations designed to decrease their adverse effects and explore their biomedical applications.
ISSN:1021-9498
2224-6614
DOI:10.1016/j.jfda.2014.01.009