Tuning of the Hematopoietic Stem Cell Compartment in its Inflammatory Environment

Purpose of Review The hematopoietic stem cell (HSC) compartment is the cornerstone of a lifelong blood cell production but also contributes to the ability of the hematopoietic system to dynamically respond to environmental challenges. This review summarizes our knowledge about the interaction betwee...

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Bibliographic Details
Published in:Current stem cell reports 2018-09, Vol.4 (3), p.189-200
Main Authors: Govindarajah, Vinothini, Reynaud, Damien
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedical Engineering/Biotechnology
Biomedicine
Cancer and Stem Cells (D Starczynowski and G Huang
Cell Biology
Gene Therapy
Hematological diseases
Hematopoietic stem cells
Immunology
Inflammation
Life Sciences
Section Editors
Stem Cells
Topical Collection on Cancer and Stem Cells
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Summary:Purpose of Review The hematopoietic stem cell (HSC) compartment is the cornerstone of a lifelong blood cell production but also contributes to the ability of the hematopoietic system to dynamically respond to environmental challenges. This review summarizes our knowledge about the interaction between HSCs and its inflammatory environment during life and questions how its disruption could affect the health of the hematopoietic system. Recent Findings The latest research demonstrates the direct role of inflammatory signals in promoting the emergence of the HSCs during development and in setting their steady-state activity in adults. They indicate that inflammatory patho-physiological conditions or immunological history could shape the structure and biology of the HSC compartment, therefore altering its overall fitness. Summary Through instructive and/or selective mechanisms, the inflammatory environment seems to provide a key homeostatic signal for HSCs. Although the mechanistic basis of this complex interplay remains to be fully understood, its dysregulation has broad consequences on HSC physiology and the development of hematological diseases. As such, developing experimental models that fully recapitulate a normal basal inflammatory state could be essential to fully assess HSC biology in native conditions.
ISSN:2198-7866
2198-7866
DOI:10.1007/s40778-018-0131-y