Low-Density Lipoprotein Receptor-Related Proteins in Skeletal Development and Disease

The identification of the low-density lipoprotein receptor (LDLR) provided a foundation for subsequent studies in lipoprotein metabolism, receptor-mediated endocytosis, and many other fundamental biological functions. The importance of the LDLR led to numerous studies that identified homologous mole...

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Bibliographic Details
Published in:Physiological reviews 2017-07, Vol.97 (3), p.1211-1228
Main Authors: Yang, Tao, Williams, Bart O
Format: Article
Language:English
Subjects:
Animals
Bone and Bones - metabolism
Bone and Bones - pathology
Bone and Bones - physiopathology
Bone Diseases - genetics
Bone Diseases - metabolism
Bone Diseases - pathology
Bone Diseases - physiopathology
Bone Regeneration
Disease Models, Animal
Genetic Predisposition to Disease
Humans
LDL-Receptor Related Proteins - genetics
LDL-Receptor Related Proteins - metabolism
Mice, Transgenic
Osteogenesis
Phenotype
Review
Signal Transduction
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Summary:The identification of the low-density lipoprotein receptor (LDLR) provided a foundation for subsequent studies in lipoprotein metabolism, receptor-mediated endocytosis, and many other fundamental biological functions. The importance of the LDLR led to numerous studies that identified homologous molecules and ultimately resulted in the description of the LDL-receptor superfamily, a group of proteins that contain domains also found in the LDLR. Subsequent studies have revealed that members of the LDLR-related protein family play roles in regulating many aspects of signal transduction. This review is focused on the roles of selected members of this protein family in skeletal development and disease. We present background on the identification of this subgroup of receptors, discuss the phenotypes associated with alterations in their function in human patients and mouse models, and describe the current efforts to therapeutically target these proteins to treat human skeletal disease.
ISSN:0031-9333
1522-1210
DOI:10.1152/physrev.00013.2016