Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence

Nicotinamide adenine dinucleotide (NAD), the cell’s hydrogen carrier for redox enzymes, is well known for its role in redox reactions. More recently, it has emerged as a signaling molecule. By modulating NAD+-sensing enzymes, NAD+ controls hundreds of key processes from energy metabolism to cell sur...

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Bibliographic Details
Published in:Cell metabolism 2018-03, Vol.27 (3), p.529-547
Main Authors: Rajman, Luis, Chwalek, Karolina, Sinclair, David A.
Format: Article
Language:English
Subjects:
aging
Animals
cancer
cardiovascular disease
CD38
chromatin
Energy Metabolism
epigenetics
Humans
inflammation
Longevity
NAD - metabolism
NAD - pharmacology
nicotinamide mononucleotide
nicotinamide riboside
PARP1
Signal Transduction
sirtuins
STAC
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Summary:Nicotinamide adenine dinucleotide (NAD), the cell’s hydrogen carrier for redox enzymes, is well known for its role in redox reactions. More recently, it has emerged as a signaling molecule. By modulating NAD+-sensing enzymes, NAD+ controls hundreds of key processes from energy metabolism to cell survival, rising and falling depending on food intake, exercise, and the time of day. NAD+ levels steadily decline with age, resulting in altered metabolism and increased disease susceptibility. Restoration of NAD+ levels in old or diseased animals can promote health and extend lifespan, prompting a search for safe and efficacious NAD-boosting molecules that hold the promise of increasing the body’s resilience, not just to one disease, but to many, thereby extending healthy human lifespan. Nicotinamide adenine dinucleotide (NAD+) has emerged as a key regulator of cellular processes that control the body’s response to stress. Rajman et al. discuss NAD boosters, small molecules that raise NAD+ levels, which are now considered to be highly promising for the treatment of multiple diseases and the potential extension of human lifespan.
ISSN:1550-4131
1932-7420
DOI:10.1016/j.cmet.2018.02.011