Tolvaptan Use to Treat SIADH in a Child

Hyponatremia is one of the most common electrolyte abnormalities encountered in the clinical setting in hospitalized patients. The syndrome of inappropriate antidiuretic hormone secretion (SIADH) is the leading cause of hyponatremia in most of these cases. While fluid restriction, hypertonic saline...

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Bibliographic Details
Published in:The journal of pediatric pharmacology and therapeutics 2018-11, Vol.23 (6), p.494-498
Main Authors: Koksoy, Adem Yasin, Kurtul, Meltem, Ozsahin, Aslı Kantar, Cayci, Fatma Semsa, Tayfun, Meltem, Bayrakci, Umut Selda
Format: Article
Language:English
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Case Reports
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Summary:Hyponatremia is one of the most common electrolyte abnormalities encountered in the clinical setting in hospitalized patients. The syndrome of inappropriate antidiuretic hormone secretion (SIADH) is the leading cause of hyponatremia in most of these cases. While fluid restriction, hypertonic saline infusion, diuretics, and the treatment of underlying conditions constitute the first line of treatment of SIADH, in refractory cases, and especially for pediatric patients, there seems not to be any other choice for treatment. Tolvaptan, although its use in pediatric patients is still very limited, might be an attractive treatment option for correction of hyponatremia due to SIADH. Here we present a pediatric case of SIADH that was resistant to treatment with fluid restriction and hypertonic saline infusion and was treated successfully with tolvaptan. Tolvaptan could be a good, safe, and effective treatment option in pediatric SIADH cases that are resistant to treatment. However, the dosage should be titrated carefully.
ISSN:1551-6776
2331-348X
DOI:10.5863/1551-6776-23.6.494