Role of ultrasonographic features and quantified BRAFV600E mutation in lymph node metastasis in Chinese patients with papillary thyroid carcinoma

The association between cervical lymph node metastasis (LNM) and ultrasonographic features as well as BRAF mutations in patients with papillary thyroid carcinoma (PTC) remained controversial. This study investigated the association between LNM and ultrasonographic features as well as BRAF mutation i...

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Bibliographic Details
Published in:Scientific reports 2019-01, Vol.9 (1), p.75-75, Article 75
Main Authors: Guo, Liang, Ma, Ya-Qi, Yao, Yao, Wu, Meng, Deng, Zi-Hui, Zhu, Feng-Wei, Luo, Yu-Kun, Tang, Jie
Format: Article
Language:English
Subjects:
Adult
Asian Continental Ancestry Group
China
Female
Genetic Predisposition to Disease
Head and Neck Neoplasms - genetics
Head and Neck Neoplasms - pathology
Head and Neck Neoplasms - secondary
Humans
Immunohistochemistry
Lymph nodes
Lymph Nodes - pathology
Lymphatic system
Male
Metastases
Metastasis
Middle Aged
Mutation
Mutation, Missense
Papillary thyroid carcinoma
Proto-Oncogene Proteins B-raf - genetics
Thyroid
Thyroid cancer
Thyroid Cancer, Papillary - diagnostic imaging
Thyroid Cancer, Papillary - genetics
Thyroid Cancer, Papillary - pathology
Ultrasonography
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Summary:The association between cervical lymph node metastasis (LNM) and ultrasonographic features as well as BRAF mutations in patients with papillary thyroid carcinoma (PTC) remained controversial. This study investigated the association between LNM and ultrasonographic features as well as BRAF mutation in Chinese patients with PTC. A total of 280 patients with PTC in China were included in this study. 108 had cervical lymph node metastasis, while 172 had not. Younger age (
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-018-36171-z