SNCA overexpression disturbs hippocampal gene expression trajectories in midlife

Synucleinopathies like Parkinson's disease and dementia with Lewy bodies originate from a complex and still largely enigmatic interplay of genetic predisposition, age, and environmental factors. While progressively declining motor functions hallmark late-life symptoms, first signs of the diseas...

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Published in:Aging (Albany, NY.) NY.), 2018-12, Vol.10 (12), p.4024-4041
Main Authors: Hentrich, Thomas, Wassouf, Zinah, Riess, Olaf, Schulze-Hentrich, Julia M
Format: Article
Language:English
Subjects:
Aging - physiology
alpha-Synuclein - genetics
alpha-Synuclein - metabolism
Animals
Gene Expression Regulation - physiology
Hippocampus - metabolism
Mice
Mice, Transgenic
Research Paper
Stress, Physiological
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Summary:Synucleinopathies like Parkinson's disease and dementia with Lewy bodies originate from a complex and still largely enigmatic interplay of genetic predisposition, age, and environmental factors. While progressively declining motor functions hallmark late-life symptoms, first signs of the disease often surface already decades earlier during midlife. To better understand early disease stages with respect to the genetic, temporal, and environmental dimension, we interrogated hippocampal transcriptome data obtained during midlife for a mouse model overexpressing human , a pivotal gene in synucleinopathies, under different environments. To relate differentially expressed genes to human, we integrated expression signatures for aging and Parkinson's disease. We identified two distinctive modes of age-dependent disturbances: First, cellular processes seemingly activated too early that reflected advanced stages of age and, second, typical longitudinal adaptations of the system that no longer occurred during midlife. Environmental enrichment prevented both disturbances modes despite persistent overload. Together, our results caution the view that expression changes characterising early stages of -related pathology reflect accelerated aging alone. Instead, we provide evidence that failure to undergo healthy adaptions during midlife represents a second origin of disturbances. This bimodal disturbance principle could inform therapeutic efforts to distinguish between preventive and restorative attempts to target the disease.
ISSN:1945-4589
1945-4589
DOI:10.18632/aging.101691