Interleukin 1 Receptor-Like 1 Protein (ST2) is a Potential Biomarker for Cardiomyopathy in Duchenne Muscular Dystrophy

Duchenne muscular dystrophy (DMD) is a rare, fatal X-linked disorder characterized by the lack of dystrophin, a key sarcolemma muscle protein. Cardiac failure is a significant cause of death in DMD subjects. The purpose of our research was to identify potential cardiac serum biomarkers associated wi...

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Bibliographic Details
Published in:Pediatric cardiology 2017-12, Vol.38 (8), p.1606-1612
Main Authors: Anderson, Julia, Seol, Haeri, Gordish-Dressman, Heather, Hathout, Yetrib, Spurney, Christopher F.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biomarkers - blood
Cardiac Surgery
Cardiology
Cardiomyopathies - blood
Cardiomyopathies - etiology
Cardiomyopathy
Case-Control Studies
Comparative analysis
Duchenne muscular dystrophy
Dystrophin
Enzyme-Linked Immunosorbent Assay
Heart diseases
Heart failure
Humans
Interleukin-1 Receptor-Like 1 Protein - blood
Interleukins
Linear Models
Male
Medicine
Medicine & Public Health
Muscular Dystrophy, Duchenne - blood
Muscular Dystrophy, Duchenne - complications
Original Article
Stroke Volume
Utrophin
Vascular Surgery
Young Adult
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Summary:Duchenne muscular dystrophy (DMD) is a rare, fatal X-linked disorder characterized by the lack of dystrophin, a key sarcolemma muscle protein. Cardiac failure is a significant cause of death in DMD subjects. The purpose of our research was to identify potential cardiac serum biomarkers associated with DMD cardiomyopathy. This is an observational, case-controlled study using subjects from the CINRG DMD natural history study with cardiomyopathy (ejection fraction (EF)
ISSN:0172-0643
1432-1971
DOI:10.1007/s00246-017-1703-9