Multicompartment Theranostic Nanoemulsions Stabilized by a Triphilic Semifluorinated Block Copolymer

The presence of a perfluorocarbon block in a multiblock polymer has been shown to be an additional driving force toward nanoparticle assembly. In the preparation of nanoemulsions, this perfluorocarbon block also provides enhanced particle stability. Herein, the synthesis of a new triphilic, semifluo...

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Bibliographic Details
Published in:Molecular pharmaceutics 2017-11, Vol.14 (11), p.3916-3926
Main Authors: Barres, Alexa R, Wimmer, Megan R, Mecozzi, Sandro
Format: Article
Language:English
Subjects:
Cell Line, Tumor
Drug Carriers - chemistry
Drug Delivery Systems - methods
Humans
Magnetic Resonance Imaging - methods
Nanoparticles - chemistry
Polymers - chemistry
Theranostic Nanomedicine - methods
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Summary:The presence of a perfluorocarbon block in a multiblock polymer has been shown to be an additional driving force toward nanoparticle assembly. In the preparation of nanoemulsions, this perfluorocarbon block also provides enhanced particle stability. Herein, the synthesis of a new triphilic, semifluorinated copolymer, M2F8H18, is introduced. This ABC type block copolymer can be used to formulate extremely stable nanoemulsions, assembled around a lipophilic droplet, with lifetimes of one year or more. The central oil droplet can stably solubilize high concentrations of hydrophobic drugs, making this system an ideal drug delivery vehicle. The incorporation of the perfluorocarbon block modulates drug release from the lipophilic core via the surrounding fluorous shell. Fluorous imaging agents incorporated into the fluorous shell prolong drug release even further as well as provide potent 19F-MRI contrast ability. In vitro studies show that these nanoemulsions efficiently inhibit cancer cell growth, thus providing a theranostic drug delivery system.
ISSN:1543-8384
1543-8392
DOI:10.1021/acs.molpharmaceut.7b00624