Air pollutant particulate matter 2.5 induces dry eye syndrome in mice

In this study, we explored the effects of particulate matter 2.5 (PM ) eye drops on the ocular surface structure and tear function in mice and established a novel animal model for dry eye research. We found that, following treatment with PM , the tear volume and, the tear film break-up time showed s...

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Bibliographic Details
Published in:Scientific reports 2018-12, Vol.8 (1), p.17828-13, Article 17828
Main Authors: Tan, Gang, Li, Juan, Yang, Qichen, Wu, Anhua, Qu, Dong-Yi, Wang, Yahong, Ye, Lei, Bao, Jing, Shao, Yi
Format: Article
Language:English
Subjects:
Air Pollutants - toxicity
Air pollution
Animals
Apoptosis
Cell Line, Transformed
Cell Proliferation - drug effects
Cornea
Desmosomes
Disease Models, Animal
Dry Eye Syndromes - chemically induced
Dry Eye Syndromes - metabolism
Dry Eye Syndromes - pathology
Epithelium
Epithelium, Corneal - metabolism
Epithelium, Corneal - ultrastructure
Eye
Eye Proteins - biosynthesis
Fornix
Gene Expression Regulation - drug effects
Goblet cells
Humans
Mice
Mice, Inbred BALB C
Microscopy
NF-κB protein
Particulate matter
Particulate Matter - toxicity
Scanning electron microscopy
Structure-function relationships
Transmission electron microscopy
Tumor necrosis factor-α
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Summary:In this study, we explored the effects of particulate matter 2.5 (PM ) eye drops on the ocular surface structure and tear function in mice and established a novel animal model for dry eye research. We found that, following treatment with PM , the tear volume and, the tear film break-up time showed statistical differences at each time point (P 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-018-36181-x