Intussusception hospitalizations before rotavirus vaccine introduction: Retrospective data from two referral hospitals in Tamil Nadu, India

The indigenous oral rotavirus vaccine Rotavac® was introduced into the public immunization system in India in 2016 and will be expanded in phases. This data will describe the epidemiology of intussusception in India in absence of rotavirus vaccination and will help in setting up or designing a safet...

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Bibliographic Details
Published in:Vaccine 2018-12, Vol.36 (51), p.7820-7825
Main Authors: Srinivasan, Rajan, Girish Kumar, C.P., Naaraayan, Sridevi A., Jehangir, Susan, Thangaraj, Jeromie W.V., Venkatasubramanian, S., Kang, Gagandeep
Format: Article
Language:English
Subjects:
Abdomen
Age
Barium
Child, Preschool
Children
Diarrhea
Epidemiology
Female
Females
Hospitalization - statistics & numerical data
Hospitals
Humans
Immunization
India - epidemiology
Infant
Infant, Newborn
Intussusception
Intussusception - diagnosis
Intussusception - epidemiology
Male
Medical Records
Monitoring
Mortality
Pain
Pediatrics
Population Surveillance
Referral and Consultation - statistics & numerical data
Retrospective Studies
Retrospective surveillance
Rotavirus
Rotavirus Infections - prevention & control
Rotavirus vaccine
Surgery
Ultrasonic imaging
Vaccination
Vaccination - statistics & numerical data
Vaccines
Viruses
Vomiting
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Summary:The indigenous oral rotavirus vaccine Rotavac® was introduced into the public immunization system in India in 2016 and will be expanded in phases. This data will describe the epidemiology of intussusception in India in absence of rotavirus vaccination and will help in setting up or designing a safety monitoring system. Medical records of intussusception cases between 2013 and 2016 in two major referral hospitals in Tamil Nadu, India were reviewed, and data on clinical presentation and management and outcome were collated. A total of 284 cases of intussusception were diagnosed and managed at the two centers of which 280/284 could be classified as level 1 by the Brighton criteria. Median age at presentation was 8 months (Inter Quartile Range, IQR 6–17.2) with a male to female ratio of 2.1:1. Over half (57.7%) required surgical intervention while the rest underwent non-surgical or conservative management. Retrospective data from referral hospitals is sufficient to classify cases of intussusception by the Brighton criteria. These baseline data will be useful for monitoring when rotavirus vaccination is introduced.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2017.11.043