Therapeutic drug monitoring of small molecule kinase inhibitors in oncology in a real‐world cohort study: does age matter?

Aim Pharmacokinetics of small molecule kinase inhibitors (KIs) used in cancer treatment may alter with increasing age, but results are conflicting. This study aims to compare exposure to KIs between older and younger patients (≥70 and

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Bibliographic Details
Published in:British journal of clinical pharmacology 2018-12, Vol.84 (12), p.2770-2778
Main Authors: Crombag, Marie‐Rose B.S., Doremalen, Jacobine G.C., Janssen, Julie M., Rosing, Hilde, Schellens, Jan H.M., Beijnen, Jos H., Steeghs, Neeltje, Huitema, Alwin D.R.
Format: Article
Language:English
Subjects:
Adult
Age Factors
Aged
Aged, 80 and over
anticancer drugs
Antineoplastic Agents - blood
Cohort Studies
Drug Monitoring
elderly
Female
Humans
Male
Middle Aged
Neoplasms - drug therapy
Original
pharmacokinetics
Protein Kinase Inhibitors - blood
therapeutic drug monitoring
Young Adult
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Description
Summary:Aim Pharmacokinetics of small molecule kinase inhibitors (KIs) used in cancer treatment may alter with increasing age, but results are conflicting. This study aims to compare exposure to KIs between older and younger patients (≥70 and
ISSN:0306-5251
1365-2125
DOI:10.1111/bcp.13725