Implantable Tin Porphyrin-PEG Hydrogels with pH-Responsive Fluorescence

Tetracarboxy porphyrins can be polymerized with polyethylene glycol (PEG) diamines to generate hydrogels with intense, near-infrared, and transdermal fluorescence following subcutaneous implantation. Here, we show that the high density porphyrins of the preformed polymer can be chelated with tin via...

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Bibliographic Details
Published in:Biomacromolecules 2017-02, Vol.18 (2), p.562-567
Main Authors: Huang, Haoyuan, Chauhan, Saurabh, Geng, Jumin, Qin, Yiru, Watson, David F, Lovell, Jonathan F
Format: Article
Language:English
Subjects:
Animals
Fluorescence
Hydrogels - chemistry
Hydrogen-Ion Concentration
Mice
Polyethylene Glycols - chemistry
Polymers - administration & dosage
Polymers - chemistry
Porphyrins - chemistry
Prostheses and Implants
Spectrometry, Fluorescence
Tin - chemistry
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Summary:Tetracarboxy porphyrins can be polymerized with polyethylene glycol (PEG) diamines to generate hydrogels with intense, near-infrared, and transdermal fluorescence following subcutaneous implantation. Here, we show that the high density porphyrins of the preformed polymer can be chelated with tin via simple incubation. Tin porphyrin hydrogels exhibited increasing emission intensities, ratios, and lifetimes from pH 1 to 10. Tin porphyrin hydrogel emission was strongly reversible and pH responsiveness was observed in the physiological range between pH 6 and pH 8. pH-sensitive emission was detected via noninvasive transdermal fluorescence imaging in vivo following subcutaneous implantation in mice.
ISSN:1525-7797
1526-4602
DOI:10.1021/acs.biomac.6b01715