Hybrid Paper–Plastic Microchip for Flexible and High‐Performance Point‐of‐Care Diagnostics

A low‐cost and easy‐to‐fabricate microchip remains a key challenge for the development of true point‐of‐care (POC) diagnostics. Cellulose paper and plastic are thin, light, flexible, and abundant raw materials, which make them excellent substrates for mass production of POC devices. Herein, a hybrid...

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Bibliographic Details
Published in:Advanced functional materials 2018-06, Vol.28 (26), p.n/a
Main Authors: Draz, Mohamed Shehata, Moazeni, Maryam, Venkataramani, Manasa, Lakshminarayanan, Harini, Saygili, Ecem, Lakshminaraasimulu, Nivethitha Kota, Kochehbyoki, Kamyar Mehrabi, Kanakasabapathy, Manoj Kumar, Shabahang, Shirin, Vasan, Anish, Bijarchi, Mohamad Ali, Memic, Adnan, Shafiee, Hadi
Format: Article
Language:English
Subjects:
Biomarkers
Cancer
Cellulosic resins
Colon
electrical sensing
flexible electronics
Liver
Mass production
Materials science
Microorganisms
paper microfluidics
plastic microfluidics
point‐of‐care diagnostics
Proteins
Raw materials
Semiconductors
Substrates
Target detection
Viruses
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Summary:A low‐cost and easy‐to‐fabricate microchip remains a key challenge for the development of true point‐of‐care (POC) diagnostics. Cellulose paper and plastic are thin, light, flexible, and abundant raw materials, which make them excellent substrates for mass production of POC devices. Herein, a hybrid paper–plastic microchip (PPMC) is developed, which can be used for both single and multiplexed detection of different targets, providing flexibility in the design and fabrication of the microchip. The developed PPMC with printed electronics is evaluated for sensitive and reliable detection of a broad range of targets, such as liver and colon cancer protein biomarkers, intact Zika virus, and human papillomavirus nucleic acid amplicons. The presented approach allows a highly specific detection of the tested targets with detection limits as low as 102 ng mL−1 for protein biomarkers, 103 particle per milliliter for virus particles, and 102 copies per microliter for a target nucleic acid. This approach can potentially be considered for the development of inexpensive and stable POC microchip diagnostics and is suitable for the detection of a wide range of microbial infections and cancer biomarkers. Cellulose paper and plastic are thin, light, flexible, and abundant raw materials, and represent excellent substrates for mass production of point‐of‐care diagnostics. This work describes a new category of hybrid flexible electronic systems that integrates cellulose paper and plastic substrates for the detection of nucleic acid, intact virus particles, and cancer protein biomarkers.
ISSN:1616-301X
1616-3028
DOI:10.1002/adfm.201707161