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Effects of Bifidobacterium probiotic on the treatment of chronic periodontitis: A randomized clinical trial
Aim This randomized placebo‐controlled clinical trial evaluated the effect of Bifidobacterium animalis subsp. lactis (B. lactis) HN019‐containing probiotic lozenges as adjuvant to scaling and root planing (SRP) in patients with generalized chronic periodontitis. Materials and Methods Forty‐one chron...
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| Published in: | Journal of clinical periodontology 2018-10, Vol.45 (10), p.1198-1210 |
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| Main Authors: | , , , , , , , , , , |
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| container_end_page | 1210 |
| container_issue | 10 |
| container_start_page | 1198 |
| container_title | Journal of clinical periodontology |
| container_volume | 45 |
| creator | Invernici, Marcos M. Salvador, Sérgio L. Silva, Pedro H. F. Soares, Mariana S. M. Casarin, Renato Palioto, Daniela B. Souza, Sérgio L. S. Taba, Mario Novaes, Arthur B. Furlaneto, Flávia A. C. Messora, Michel R. |
| description | Aim
This randomized placebo‐controlled clinical trial evaluated the effect of Bifidobacterium animalis subsp. lactis (B. lactis) HN019‐containing probiotic lozenges as adjuvant to scaling and root planing (SRP) in patients with generalized chronic periodontitis.
Materials and Methods
Forty‐one chronic periodontitis patients were recruited and monitored clinically, immunologically, and microbiologically at baseline (before SRP) and 30 and 90 days after SRP. All patients were randomly assigned to a Test (SRP + Probiotic, n = 20) or Control (SRP + Placebo, n = 21) group. The probiotic lozenges were used twice a day for 30 days. The data were statistically analysed.
Results
The Test group presented a decrease in probing pocket depth and a clinical attachment gain significantly higher than those of the Control group at 90 days. The Test group also demonstrated significantly fewer periodontal pathogens of red and orange complexes, as well as lower proinflammatory cytokine levels when compared to the Control group. Only the Test group showed an increase in the number of B. lactis HN019 DNA copies on subgingival biofilm at 30 and 90 days.
Conclusion
The use of B. lactis HN019 as an adjunct to SRP promotes additional clinical, microbiological, and immunological benefits in the treatment of chronic periodontitis (NCT03408548). |
| doi_str_mv | 10.1111/jcpe.12995 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6221043</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2083709172</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5145-a5d579471aa5e110dd9cfdee1dbdb4fb377431f4effea3f5ff8c71491c98a6e73</originalsourceid><addsrcrecordid>eNp9kU2LFDEQhoMo7rh68QdIwIsIvaY6nc60B2Edxi8W9KDgLaSTipOxu9ObpJX115tx1kU9WJc61JOHN7yEPAR2BmWe7c2MZ1B3nbhFVtAyVjEBn2-TFeOMV20nuxNyL6U9YyA553fJCWdMti3wFfm6dQ5NTjQ4-tI7b0OvTcbol5HOMfQ-ZG9omGjeIc0RdR5xygfa7GKYym0ucLBhyj779Jye06gnG0b_Ay01gy-IHspLr4f75I7TQ8IH1_uUfHq1_bh5U128f_12c35RGQGNqLSwQnaNBK0FAjBrO-MsItje9o3ruZQNB9dgSa65E86tjYSmA9OtdYuSn5IXR--89CNaUwJHPag5-lHHKxW0V39fJr9TX8I31dY1sIYXwZNrQQyXC6asRp8MDoOeMCxJ1WzNJetA1gV9_A-6D0ucyvdUDTVwIaFtC_X0SJkYUorobsIAU4cO1aFD9avDAj_6M_4N-ru0AsAR-O4HvPqPSr3bfNgepT8BQgeqIw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2121357166</pqid></control><display><type>article</type><title>Effects of Bifidobacterium probiotic on the treatment of chronic periodontitis: A randomized clinical trial</title><source>Wiley-Blackwell Read & Publish Collection</source><creator>Invernici, Marcos M. ; Salvador, Sérgio L. ; Silva, Pedro H. F. ; Soares, Mariana S. M. ; Casarin, Renato ; Palioto, Daniela B. ; Souza, Sérgio L. S. ; Taba, Mario ; Novaes, Arthur B. ; Furlaneto, Flávia A. C. ; Messora, Michel R.</creator><creatorcontrib>Invernici, Marcos M. ; Salvador, Sérgio L. ; Silva, Pedro H. F. ; Soares, Mariana S. M. ; Casarin, Renato ; Palioto, Daniela B. ; Souza, Sérgio L. S. ; Taba, Mario ; Novaes, Arthur B. ; Furlaneto, Flávia A. C. ; Messora, Michel R.</creatorcontrib><description>Aim
This randomized placebo‐controlled clinical trial evaluated the effect of Bifidobacterium animalis subsp. lactis (B. lactis) HN019‐containing probiotic lozenges as adjuvant to scaling and root planing (SRP) in patients with generalized chronic periodontitis.
Materials and Methods
Forty‐one chronic periodontitis patients were recruited and monitored clinically, immunologically, and microbiologically at baseline (before SRP) and 30 and 90 days after SRP. All patients were randomly assigned to a Test (SRP + Probiotic, n = 20) or Control (SRP + Placebo, n = 21) group. The probiotic lozenges were used twice a day for 30 days. The data were statistically analysed.
Results
The Test group presented a decrease in probing pocket depth and a clinical attachment gain significantly higher than those of the Control group at 90 days. The Test group also demonstrated significantly fewer periodontal pathogens of red and orange complexes, as well as lower proinflammatory cytokine levels when compared to the Control group. Only the Test group showed an increase in the number of B. lactis HN019 DNA copies on subgingival biofilm at 30 and 90 days.
Conclusion
The use of B. lactis HN019 as an adjunct to SRP promotes additional clinical, microbiological, and immunological benefits in the treatment of chronic periodontitis (NCT03408548).</description><identifier>ISSN: 0303-6979</identifier><identifier>EISSN: 1600-051X</identifier><identifier>DOI: 10.1111/jcpe.12995</identifier><identifier>PMID: 30076613</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Bifidobacterium ; Bifidobacterium lactis ; Biofilms ; Chronic Periodontitis ; Clinical trials ; Data processing ; Dental Scaling ; Deoxyribonucleic acid ; DNA ; Gum disease ; Humans ; Inflammation ; Patients ; Periodontal Therapy ; Periodontitis ; Probiotics ; Randomized Clinical Trial ; Root Planing ; Scaling</subject><ispartof>Journal of clinical periodontology, 2018-10, Vol.45 (10), p.1198-1210</ispartof><rights>2018 The Authors Journal of Clinical Periodontology Published by John Wiley & Sons Ltd</rights><rights>2018 The Authors Journal of Clinical Periodontology Published by John Wiley & Sons Ltd.</rights><rights>Copyright © 2018 John Wiley & Sons A/S</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5145-a5d579471aa5e110dd9cfdee1dbdb4fb377431f4effea3f5ff8c71491c98a6e73</citedby><cites>FETCH-LOGICAL-c5145-a5d579471aa5e110dd9cfdee1dbdb4fb377431f4effea3f5ff8c71491c98a6e73</cites><orcidid>0000-0001-8485-9645 ; 0000-0002-6199-7348 ; 0000-0002-1982-6756 ; 0000-0002-7098-5090</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,315,783,787,888,27936,27937</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30076613$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Invernici, Marcos M.</creatorcontrib><creatorcontrib>Salvador, Sérgio L.</creatorcontrib><creatorcontrib>Silva, Pedro H. F.</creatorcontrib><creatorcontrib>Soares, Mariana S. M.</creatorcontrib><creatorcontrib>Casarin, Renato</creatorcontrib><creatorcontrib>Palioto, Daniela B.</creatorcontrib><creatorcontrib>Souza, Sérgio L. S.</creatorcontrib><creatorcontrib>Taba, Mario</creatorcontrib><creatorcontrib>Novaes, Arthur B.</creatorcontrib><creatorcontrib>Furlaneto, Flávia A. C.</creatorcontrib><creatorcontrib>Messora, Michel R.</creatorcontrib><title>Effects of Bifidobacterium probiotic on the treatment of chronic periodontitis: A randomized clinical trial</title><title>Journal of clinical periodontology</title><addtitle>J Clin Periodontol</addtitle><description>Aim
This randomized placebo‐controlled clinical trial evaluated the effect of Bifidobacterium animalis subsp. lactis (B. lactis) HN019‐containing probiotic lozenges as adjuvant to scaling and root planing (SRP) in patients with generalized chronic periodontitis.
Materials and Methods
Forty‐one chronic periodontitis patients were recruited and monitored clinically, immunologically, and microbiologically at baseline (before SRP) and 30 and 90 days after SRP. All patients were randomly assigned to a Test (SRP + Probiotic, n = 20) or Control (SRP + Placebo, n = 21) group. The probiotic lozenges were used twice a day for 30 days. The data were statistically analysed.
Results
The Test group presented a decrease in probing pocket depth and a clinical attachment gain significantly higher than those of the Control group at 90 days. The Test group also demonstrated significantly fewer periodontal pathogens of red and orange complexes, as well as lower proinflammatory cytokine levels when compared to the Control group. Only the Test group showed an increase in the number of B. lactis HN019 DNA copies on subgingival biofilm at 30 and 90 days.
Conclusion
The use of B. lactis HN019 as an adjunct to SRP promotes additional clinical, microbiological, and immunological benefits in the treatment of chronic periodontitis (NCT03408548).</description><subject>Bifidobacterium</subject><subject>Bifidobacterium lactis</subject><subject>Biofilms</subject><subject>Chronic Periodontitis</subject><subject>Clinical trials</subject><subject>Data processing</subject><subject>Dental Scaling</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>Gum disease</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Patients</subject><subject>Periodontal Therapy</subject><subject>Periodontitis</subject><subject>Probiotics</subject><subject>Randomized Clinical Trial</subject><subject>Root Planing</subject><subject>Scaling</subject><issn>0303-6979</issn><issn>1600-051X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><recordid>eNp9kU2LFDEQhoMo7rh68QdIwIsIvaY6nc60B2Edxi8W9KDgLaSTipOxu9ObpJX115tx1kU9WJc61JOHN7yEPAR2BmWe7c2MZ1B3nbhFVtAyVjEBn2-TFeOMV20nuxNyL6U9YyA553fJCWdMti3wFfm6dQ5NTjQ4-tI7b0OvTcbol5HOMfQ-ZG9omGjeIc0RdR5xygfa7GKYym0ucLBhyj779Jye06gnG0b_Ay01gy-IHspLr4f75I7TQ8IH1_uUfHq1_bh5U128f_12c35RGQGNqLSwQnaNBK0FAjBrO-MsItje9o3ruZQNB9dgSa65E86tjYSmA9OtdYuSn5IXR--89CNaUwJHPag5-lHHKxW0V39fJr9TX8I31dY1sIYXwZNrQQyXC6asRp8MDoOeMCxJ1WzNJetA1gV9_A-6D0ucyvdUDTVwIaFtC_X0SJkYUorobsIAU4cO1aFD9avDAj_6M_4N-ru0AsAR-O4HvPqPSr3bfNgepT8BQgeqIw</recordid><startdate>201810</startdate><enddate>201810</enddate><creator>Invernici, Marcos M.</creator><creator>Salvador, Sérgio L.</creator><creator>Silva, Pedro H. F.</creator><creator>Soares, Mariana S. M.</creator><creator>Casarin, Renato</creator><creator>Palioto, Daniela B.</creator><creator>Souza, Sérgio L. S.</creator><creator>Taba, Mario</creator><creator>Novaes, Arthur B.</creator><creator>Furlaneto, Flávia A. C.</creator><creator>Messora, Michel R.</creator><general>Blackwell Publishing Ltd</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-8485-9645</orcidid><orcidid>https://orcid.org/0000-0002-6199-7348</orcidid><orcidid>https://orcid.org/0000-0002-1982-6756</orcidid><orcidid>https://orcid.org/0000-0002-7098-5090</orcidid></search><sort><creationdate>201810</creationdate><title>Effects of Bifidobacterium probiotic on the treatment of chronic periodontitis: A randomized clinical trial</title><author>Invernici, Marcos M. ; Salvador, Sérgio L. ; Silva, Pedro H. F. ; Soares, Mariana S. M. ; Casarin, Renato ; Palioto, Daniela B. ; Souza, Sérgio L. S. ; Taba, Mario ; Novaes, Arthur B. ; Furlaneto, Flávia A. C. ; Messora, Michel R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5145-a5d579471aa5e110dd9cfdee1dbdb4fb377431f4effea3f5ff8c71491c98a6e73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Bifidobacterium</topic><topic>Bifidobacterium lactis</topic><topic>Biofilms</topic><topic>Chronic Periodontitis</topic><topic>Clinical trials</topic><topic>Data processing</topic><topic>Dental Scaling</topic><topic>Deoxyribonucleic acid</topic><topic>DNA</topic><topic>Gum disease</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Patients</topic><topic>Periodontal Therapy</topic><topic>Periodontitis</topic><topic>Probiotics</topic><topic>Randomized Clinical Trial</topic><topic>Root Planing</topic><topic>Scaling</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Invernici, Marcos M.</creatorcontrib><creatorcontrib>Salvador, Sérgio L.</creatorcontrib><creatorcontrib>Silva, Pedro H. F.</creatorcontrib><creatorcontrib>Soares, Mariana S. M.</creatorcontrib><creatorcontrib>Casarin, Renato</creatorcontrib><creatorcontrib>Palioto, Daniela B.</creatorcontrib><creatorcontrib>Souza, Sérgio L. S.</creatorcontrib><creatorcontrib>Taba, Mario</creatorcontrib><creatorcontrib>Novaes, Arthur B.</creatorcontrib><creatorcontrib>Furlaneto, Flávia A. C.</creatorcontrib><creatorcontrib>Messora, Michel R.</creatorcontrib><collection>Wiley_OA刊</collection><collection>Wiley Online Library Free Content</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of clinical periodontology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Invernici, Marcos M.</au><au>Salvador, Sérgio L.</au><au>Silva, Pedro H. F.</au><au>Soares, Mariana S. M.</au><au>Casarin, Renato</au><au>Palioto, Daniela B.</au><au>Souza, Sérgio L. S.</au><au>Taba, Mario</au><au>Novaes, Arthur B.</au><au>Furlaneto, Flávia A. C.</au><au>Messora, Michel R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Bifidobacterium probiotic on the treatment of chronic periodontitis: A randomized clinical trial</atitle><jtitle>Journal of clinical periodontology</jtitle><addtitle>J Clin Periodontol</addtitle><date>2018-10</date><risdate>2018</risdate><volume>45</volume><issue>10</issue><spage>1198</spage><epage>1210</epage><pages>1198-1210</pages><issn>0303-6979</issn><eissn>1600-051X</eissn><abstract>Aim
This randomized placebo‐controlled clinical trial evaluated the effect of Bifidobacterium animalis subsp. lactis (B. lactis) HN019‐containing probiotic lozenges as adjuvant to scaling and root planing (SRP) in patients with generalized chronic periodontitis.
Materials and Methods
Forty‐one chronic periodontitis patients were recruited and monitored clinically, immunologically, and microbiologically at baseline (before SRP) and 30 and 90 days after SRP. All patients were randomly assigned to a Test (SRP + Probiotic, n = 20) or Control (SRP + Placebo, n = 21) group. The probiotic lozenges were used twice a day for 30 days. The data were statistically analysed.
Results
The Test group presented a decrease in probing pocket depth and a clinical attachment gain significantly higher than those of the Control group at 90 days. The Test group also demonstrated significantly fewer periodontal pathogens of red and orange complexes, as well as lower proinflammatory cytokine levels when compared to the Control group. Only the Test group showed an increase in the number of B. lactis HN019 DNA copies on subgingival biofilm at 30 and 90 days.
Conclusion
The use of B. lactis HN019 as an adjunct to SRP promotes additional clinical, microbiological, and immunological benefits in the treatment of chronic periodontitis (NCT03408548).</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>30076613</pmid><doi>10.1111/jcpe.12995</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0001-8485-9645</orcidid><orcidid>https://orcid.org/0000-0002-6199-7348</orcidid><orcidid>https://orcid.org/0000-0002-1982-6756</orcidid><orcidid>https://orcid.org/0000-0002-7098-5090</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of clinical periodontology, 2018-10, Vol.45 (10), p.1198-1210 |
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| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Bifidobacterium Bifidobacterium lactis Biofilms Chronic Periodontitis Clinical trials Data processing Dental Scaling Deoxyribonucleic acid DNA Gum disease Humans Inflammation Patients Periodontal Therapy Periodontitis Probiotics Randomized Clinical Trial Root Planing Scaling |
| title | Effects of Bifidobacterium probiotic on the treatment of chronic periodontitis: A randomized clinical trial |
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