Effects of Bifidobacterium probiotic on the treatment of chronic periodontitis: A randomized clinical trial

Aim This randomized placebo‐controlled clinical trial evaluated the effect of Bifidobacterium animalis subsp. lactis (B. lactis) HN019‐containing probiotic lozenges as adjuvant to scaling and root planing (SRP) in patients with generalized chronic periodontitis. Materials and Methods Forty‐one chron...

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Published in:Journal of clinical periodontology 2018-10, Vol.45 (10), p.1198-1210
Main Authors: Invernici, Marcos M., Salvador, Sérgio L., Silva, Pedro H. F., Soares, Mariana S. M., Casarin, Renato, Palioto, Daniela B., Souza, Sérgio L. S., Taba, Mario, Novaes, Arthur B., Furlaneto, Flávia A. C., Messora, Michel R.
Format: Article
Language:English
Subjects:
Bifidobacterium
Bifidobacterium lactis
Biofilms
Chronic Periodontitis
Clinical trials
Data processing
Dental Scaling
Deoxyribonucleic acid
DNA
Gum disease
Humans
Inflammation
Patients
Periodontal Therapy
Periodontitis
Probiotics
Randomized Clinical Trial
Root Planing
Scaling
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Summary:Aim This randomized placebo‐controlled clinical trial evaluated the effect of Bifidobacterium animalis subsp. lactis (B. lactis) HN019‐containing probiotic lozenges as adjuvant to scaling and root planing (SRP) in patients with generalized chronic periodontitis. Materials and Methods Forty‐one chronic periodontitis patients were recruited and monitored clinically, immunologically, and microbiologically at baseline (before SRP) and 30 and 90 days after SRP. All patients were randomly assigned to a Test (SRP + Probiotic, n = 20) or Control (SRP + Placebo, n = 21) group. The probiotic lozenges were used twice a day for 30 days. The data were statistically analysed. Results The Test group presented a decrease in probing pocket depth and a clinical attachment gain significantly higher than those of the Control group at 90 days. The Test group also demonstrated significantly fewer periodontal pathogens of red and orange complexes, as well as lower proinflammatory cytokine levels when compared to the Control group. Only the Test group showed an increase in the number of B. lactis HN019 DNA copies on subgingival biofilm at 30 and 90 days. Conclusion The use of B. lactis HN019 as an adjunct to SRP promotes additional clinical, microbiological, and immunological benefits in the treatment of chronic periodontitis (NCT03408548).
ISSN:0303-6979
1600-051X
DOI:10.1111/jcpe.12995