Evaluation of a New Multiparameter Brain Probe for Simultaneous Measurement of Brain Tissue Oxygenation, Cerebral Blood Flow, Intracranial Pressure, and Brain Temperature in a Porcine Model

Background A novel multiparameter brain sensor (MPBS) allows the simultaneous measurement of brain tissue oxygenation (ptiO 2 ), cerebral blood flow (CBF), intracranial pressure (ICP), and brain temperature with a single catheter. This laboratory investigation evaluates the MPBS in an animal model i...

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Bibliographic Details
Published in:Neurocritical care 2018-10, Vol.29 (2), p.291-301
Main Authors: Mader, Marius M., Leidorf, Anna, Hecker, Andreas, Heimann, Axel, Mayr, Petra S. M., Kempski, Oliver, Alessandri, Beat, Wöbker, Gabriele
Format: Article
Language:English
Subjects:
Animals
Critical Care Medicine
Hypoxia
Intensive
Internal Medicine
Intracranial pressure
Lasers
Medicine
Medicine & Public Health
Neurology
Original
Original Article
Sensors
Trauma
Traumatic brain injury
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Summary:Background A novel multiparameter brain sensor (MPBS) allows the simultaneous measurement of brain tissue oxygenation (ptiO 2 ), cerebral blood flow (CBF), intracranial pressure (ICP), and brain temperature with a single catheter. This laboratory investigation evaluates the MPBS in an animal model in relation to established reference probes. Methods The study group consisted of 17 juvenile male pigs. Four MPBS and four reference probes were implanted per pig and compared simultaneously. The measured parameters were challenged by standardized provocations such as hyperoxia, dobutamine, and norepinephrine application, hypercapnia and hypoxia in combination with and without a controlled cortical impact (CCI) injury. Mean values over 2 min were collected for predefined time points and were analyzed using Bland–Altman plots. Results The protocol was successfully conducted in 15 pigs of which seven received CCI. ICP and ptiO 2 were significantly influenced by the provocations. Subtraction of MPBS from reference values revealed a mean difference (limits of agreement) of 3.7 (− 20.5 to 27.9) mm Hg, − 2.9 (− 7.9 to 2.1) mm Hg, and 5.1 (− 134.7 to 145.0) % for ptiO 2 , ICP, and relative CBF, respectively. Conclusions The MPBS is a promising measurement tool for multiparameter neuromonitoring. The conducted study demonstrates the in vivo functionality of the probe. Comparison with standard probes revealed a deviation which is mostly analogous to other multiparameter devices. However, further evaluation of the device is necessary before it can reliably be used for clinical decision making.
ISSN:1541-6933
1556-0961
DOI:10.1007/s12028-018-0541-9