A Methylome-Wide Association Study of Trajectories of Oppositional Defiant Behaviors and Biological Overlap With Attention Deficit Hyperactivity Disorder

In 671 mother-child (49% male) pairs from an epidemiological birth cohort, we investigated (a) prospective associations between DNA methylation (at birth) and trajectories (ages 7-13) of oppositional defiant disorder (ODD), and the ODD subdimensions of irritable and headstrong; (b) common biological...

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Bibliographic Details
Published in:Child development 2018-09, Vol.89 (5), p.1839-1855
Main Authors: Barker, Edward D., Cecil, Charlotte A.M., Jaffee, Sara R., O'Connor, Thomas G., Meehan, Alan J., Walton, Esther, Rowe, Richard, Maughan, Barbara, Stringaris, Argyris, McArdle, Wendy, Relton, Caroline L., Gaunt, Tom R.
Format: Article
Language:English
Subjects:
Adolescent
Anxiety
Attention Deficit and Disruptive Behavior Disorders - complications
Attention Deficit and Disruptive Behavior Disorders - genetics
Attention Deficit and Disruptive Behavior Disorders - psychology
Attention Deficit Disorder with Hyperactivity - complications
Attention Deficit Disorder with Hyperactivity - genetics
Attention deficit hyperactivity disorder
Biological correlates
Child
Child development
Childbirth & labor
Cigarette smoking
Cohort Studies
Deoxyribonucleic acid
DNA
DNA Methylation
Empirical
EMPIRICAL ARTICLES
Female
Humans
Irritable Mood
Male
Oppositional defiant disorder
Prenatal care
Prenatal experience
Prenatal exposure
Smoking
Symptom Assessment
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Summary:In 671 mother-child (49% male) pairs from an epidemiological birth cohort, we investigated (a) prospective associations between DNA methylation (at birth) and trajectories (ages 7-13) of oppositional defiant disorder (ODD), and the ODD subdimensions of irritable and headstrong; (b) common biological pathways, indexed by DNA methylation, between ODD trajectories and attention deficit hyperactivity disorder (ADHD); (c) genetic influence on DNA methylation; and (d) prenatal risk exposure associations. Methylome-wide significant associations were identified for the ODD and headstrong, but not for irritable. Overlap analysis indicated biological correlates between ODD, headstrong, and ADHD. DNA methylation in ODD and headstrong was (to a degree) genetically influenced. DNA methylation associated with prenatal risk exposures of maternal anxiety (headstrong) and cigarette smoking (ODD and headstrong).
ISSN:0009-3920
1467-8624
DOI:10.1111/cdev.12957