Global long non-coding RNA expression in the rostral anterior cingulate cortex of depressed suicides

Long non-coding RNAs (lncRNAs) are an emerging class of regulatory RNA that may be implicated in psychiatric disorders. Here we performed RNA-sequencing in the rostral anterior cingulate cortex of 26 depressed suicides and 24 matched controls. We first performed differential lncRNA expression analys...

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Bibliographic Details
Published in:Translational psychiatry 2018-10, Vol.8 (1), p.224-13, Article 224
Main Authors: Zhou, Yi, Lutz, Pierre-Eric, Wang, Yu Chang, Ragoussis, Jiannis, Turecki, Gustavo
Format: Article
Language:English
Subjects:
Cell adhesion & migration
Cognitive science
Depressive Disorder, Major - metabolism
Female
Gene Expression Regulation
Gyrus Cinguli - metabolism
Humans
Male
Neuroscience
Proteins
RNA, Long Noncoding - metabolism
Sequence Analysis, RNA
Suicide
Suicides & suicide attempts
Transcriptome
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Summary:Long non-coding RNAs (lncRNAs) are an emerging class of regulatory RNA that may be implicated in psychiatric disorders. Here we performed RNA-sequencing in the rostral anterior cingulate cortex of 26 depressed suicides and 24 matched controls. We first performed differential lncRNA expression analysis, and then conducted Weighted Gene Co-expression Network Analysis (WGCNA) to identify co-expression modules associating with depression and suicide. We identified 23 differentially expressed lncRNAs (FDR 
ISSN:2158-3188
2158-3188
DOI:10.1038/s41398-018-0267-7