PATHOPHYSIOLOGICAL AND BEHAVIORAL EFFECTS OF SYSTEMIC INFLAMMATION IN RODENT MODELS FOR DELIRIUM

Aging and neurodegeneration are the major predisposing factors for delirium and systemic inflammation is a frequent trigger. The aim of this review is to analyze and discuss potential animal models for delirium of inflammatory origin. We systematically reviewed animal studies using systemic inflamma...

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Bibliographic Details
Published in:	Innovation in aging 2017-07, Vol.1 (suppl_1), p.1151-1151
Main Authors:	Schreuder, L., de Rooij, S.E., Eggen, B., Biber, K., Laman, J., Schoemaker, R.
Format:	Article
Language:	eng
Subjects:	Abstracts
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Summary:	Aging and neurodegeneration are the major predisposing factors for delirium and systemic inflammation is a frequent trigger. The aim of this review is to analyze and discuss potential animal models for delirium of inflammatory origin. We systematically reviewed animal studies using systemic inflammation superimposed on animal models of aging, accelerated aging, or neurodegenerative disease. Causative agents of systemic inflammation employed by these studies include lipopolysaccharide (LPS), live infection or surgery. Our search was conducted in PubMed and EMBASE and identified 79 studies, including 65 studies using aged animals and 14 studies using diseased animals. In 46 studies animals were challenged with LPS, 7 studies challenged animals with a live infection, and in 26 studies animals underwent a surgical intervention. Outcomes of behavioral assays from animal studies were compared to features and symptoms that can be demonstrated in delirious patients. We found that some surgery models and the ME7 model of prion disease mimic several features of delirium including acute, fluctuating, and transient cognitive dysfunction and disturbance of psychomotor behavior. However, the key neuropsychological feature inattention has not been demonstrated in these models yet. Therefore, further refinement of these model systems is an important priority for future research.
ISSN:	2399-5300 2399-5300