Expression of mitofusin 2 in human sperm and its relationship to sperm motility and cryoprotective potentials

Mitofusin 2 is a kind of mitochondria membrane protein that has been implicated in maintenance of mitochondrial morphology and function. However, the expression and function of mitofusin 2 in human sperm are not well described at present. The aim of this study was to explore the location of mitofusi...

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Published in:Experimental biology and medicine (Maywood, N.J.) N.J.), 2018-08, Vol.243 (12), p.963-969
Main Authors: Fang, Fang, Ni, Ke, Shang, Jin, Zhang, Xiaoke, Xiong, Chengliang, Meng, Tianqing
Format: Article
Language:English
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Original Research
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Summary:Mitofusin 2 is a kind of mitochondria membrane protein that has been implicated in maintenance of mitochondrial morphology and function. However, the expression and function of mitofusin 2 in human sperm are not well described at present. The aim of this study was to explore the location of mitofusin 2 in human sperm and to discover its relationship to human sperm functions like motility and cryoprotective potentials. Our result showed that mitofusin 2 is specifically localized in the 5–7 μm midpiece between the neck and main part of human sperm tail. The expression level of mitofusin 2 in human sperm was significantly different between the normozoospermia and asthenozoospermia groups (P 
ISSN:1535-3702
1535-3699
DOI:10.1177/1535370218790919