Application of spin-crossover water soluble nanoparticles for use as MRI contrast agents

Water soluble spin-crossover (SCO) iron(II) nanoparticles (NPs) were synthesized by the polyethylene glycol (PEG) coating of [Fe(Htrz) (NH trz) ](BF ) (x = 0, 0.1, 0.5 and 1). The NPs with x = 0.1 show gradual SCO behavior over 280-330 K in water. The relaxation times, T1 and T2, were determined and...

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Bibliographic Details
Published in:Scientific reports 2018-10, Vol.8 (1), p.14911-5, Article 14911
Main Authors: Tsukiashi, Asami, Min, Kil Sik, Kitayama, Hikaru, Terasawa, Hiroaki, Yoshinaga, Sosuke, Takeda, Mitsuhiro, Lindoy, Leonard F, Hayami, Shinya
Format: Article
Language:English
Subjects:
Magnetic resonance imaging
Nanoparticles
Polyethylene glycol
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Summary:Water soluble spin-crossover (SCO) iron(II) nanoparticles (NPs) were synthesized by the polyethylene glycol (PEG) coating of [Fe(Htrz) (NH trz) ](BF ) (x = 0, 0.1, 0.5 and 1). The NPs with x = 0.1 show gradual SCO behavior over 280-330 K in water. The relaxation times, T1 and T2, were determined and the thermally-responsive T2 values making these NPs a candidate for use as a MRI contrast agent.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-018-33362-6