Cinnamyl Isobutyrate Decreases Plasma Glucose Levels and Total Energy Intake from a Standardized Breakfast: A Randomized, Crossover Intervention

Scope Cinnamon is associated with anti‐obesity effects, regulating food intake, improving plasma glucose levels and lipid profiles in vivo. In the present study, the impact of cinnamyl isobutyrate (CIB), one constituent of cinnamon, on ad libitum food intake from a standardized breakfast and outcome...

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Bibliographic Details
Published in:Molecular nutrition & food research 2018-09, Vol.62 (17), p.e1701038-n/a
Main Authors: Hochkogler, Christina M., Hoi, Julia K., Lieder, Barbara, Müller, Nicole, Hans, Joachim, Widder, Sabine, Ley, Jakob P., Somoza, Veronika
Format: Article
Language:English
Subjects:
Adult
Appetite
blood glucose
Blood Glucose - analysis
Blood Glucose - metabolism
Breakfast
Cinnamates - pharmacology
Cinnamon
cinnamyl isobutyrate
Crossovers
Dietary Supplements
Energy intake
Energy Intake - drug effects
Food
Food & Function
Food intake
Ghrelin
Ghrelin - blood
Glucagon
Glucagon-Like Peptide 1 - blood
Glucose
Glucose Tolerance Test
Humans
Hunger
In vivo methods and tests
Insulin
Intervention
Male
Nutrients - pharmacology
Overweight - blood
Overweight - diet therapy
Plasma
Postprandial Period
Randomization
Satiation - drug effects
satiety
Serotonin
Serotonin - blood
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Summary:Scope Cinnamon is associated with anti‐obesity effects, regulating food intake, improving plasma glucose levels and lipid profiles in vivo. In the present study, the impact of cinnamyl isobutyrate (CIB), one constituent of cinnamon, on ad libitum food intake from a standardized breakfast and outcome measures of hormonal regulation of appetite were investigated. Methods and results In this randomized, short‐term crossover intervention study, a 75 g per 300 mL glucose solution solely (control) or supplemented with 0.45 mg CIB was administered to 26 healthy volunteers. Prior to and 2 h after receiving control or CIB treatment, subjective hunger perceptions were rated using a visual analog scale. Food intake from a standardized breakfast was assessed 2 h after treatments. Plasma peptide YY3–36, glucagon‐like‐peptide1, ghrelin, and serotonin as well as plasma glucose and insulin were measured in blood samples drawn at fasting and 15, 30, 60, 90, and 120 min after treatment. CIB administration decreased total energy intake and delta area under curve plasma glucose by 4.64 ± 3.51% and 49.3 ± 18.5% compared to control treatment, respectively. Conclusions CIB, administered at a 0.45 mg bolus in 75 g glucose–water solution, decreased ad libitum energy intake from a standardized breakfast and postprandial plasma glucose levels. Cinnamon, a spice obtained from the inner bark of Cinnamomum plants and which has been used as a popular ingredient for centuries, is also known for its medicinal properties. A beneficial impact of cinnamyl isobutyrate, an aroma compound naturally occurring in cinnamon, on blood glucose levels and energy intake from a standardized breakfast is shown.
ISSN:1613-4125
1613-4133
DOI:10.1002/mnfr.201701038