Alteration of Serum Free Fatty Acids are Indicators for Progression of Pre-leukaemia Diseases to Leukaemia

Acute Leukaemia (AL) is a neoplasm of WBCs (white blood cells). Being an important class of metabolites, alteration in free fatty acids (FFAs) levels play a key role in cancer development and progression. As they involve in cell signaling, maintain membrane integrity, regulate homeostasis and effect...

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Bibliographic Details
Published in:Scientific reports 2018-10, Vol.8 (1), p.14883-10, Article 14883
Main Authors: Khalid, Ayesha, Siddiqui, Amna Jabbar, Huang, Jian-Hua, Shamsi, Tahir, Musharraf, Syed Ghulam
Format: Article
Language:English
Subjects:
Acute lymphoblastic leukemia
Acute myeloid leukemia
Anemia, Aplastic - blood
Aplastic anemia
Cancer
Disease Progression
Fatty acids
Fatty Acids, Nonesterified - blood
Female
Gas chromatography
Homeostasis
Humans
Leukemia
Leukemia, Myeloid, Acute - blood
Leukocytes
Male
Mass spectroscopy
Metabolites
Myelodysplastic syndrome
Myelodysplastic Syndromes - blood
Neoplasia
Precursor Cell Lymphoblastic Leukemia-Lymphoma - blood
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Summary:Acute Leukaemia (AL) is a neoplasm of WBCs (white blood cells). Being an important class of metabolites, alteration in free fatty acids (FFAs) levels play a key role in cancer development and progression. As they involve in cell signaling, maintain membrane integrity, regulate homeostasis and effect cell and tissue functions. Considering this fact, a comprehensive analysis of FFAs was conducted to monitor their alteration in AL, pre-leukaemic diseases and healthy control. Fifteen FFAs were analyzed in 179 serum samples of myelodysplastic syndrome (MDS), aplastic anemia (APA), acute lymphoblastic leukaemia (ALL), acute myeloid leukaemia (AML) and healthy control using gas chromatography-multiple reaction monitoring-mass spectrometry (GC-MRM-MS). A multivariate statistical method of random forest (RF) was employed for chemometric analysis. Serum level of two FFAs including C18:0 and C14:0 were found discriminative among all five groups, and between ALL and AML, respectively. Moreover, C14:0 was identified as differentiated FFAs for systematic progression of pre-leukaemic conditions towards AML. C16:0 came as discriminated FFAs between APA and MDS/AML. Over all it was identified that FFAs profile not only become altered in leukaemia but also in pre-leukaemic diseases.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-018-33224-1