Optic radiations are thinner and show signs of iron deposition in patients with long-standing remitting-relapsing multiple sclerosis: an enhanced T2-weighted angiography imaging study

Objective This study aimed to investigate iron deposition and thickness and signal changes in optic radiation (OR) by enhanced T 2 * -weighted angiography imaging (ESWAN) in patients with relapsing-remitting multiple sclerosis (RRMS) with unilateral and bilateral lesions or no lesions. Methods Fifty...

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Bibliographic Details
Published in:European radiology 2018-10, Vol.28 (10), p.4447-4454
Main Authors: Zeng, Chun, Du, Silin, Han, Yongliang, Fu, Jialiang, Luo, Qi, Xiang, Yayun, Chen, Xiaoya, Luo, Tianyou, Li, Yongmei, Zheng, Yineng
Format: Article
Language:English
Subjects:
Angiography
Deposition
Diagnostic Radiology
Imaging
Interferon
Internal Medicine
Interventional Radiology
Iron
Lesions
Magnetic Resonance
Magnetic resonance imaging
Medical imaging
Medicine
Medicine & Public Health
Multiple sclerosis
Neuroradiology
NMR
Nuclear magnetic resonance
Patients
Radiation
Radiology
Resonance
Thinning
Ultrasound
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Summary:Objective This study aimed to investigate iron deposition and thickness and signal changes in optic radiation (OR) by enhanced T 2 * -weighted angiography imaging (ESWAN) in patients with relapsing-remitting multiple sclerosis (RRMS) with unilateral and bilateral lesions or no lesions. Methods Fifty-one RRMS patients (42 patients with a disease duration [DD] ≥ 2 years [group Mor], nine patients with a DD < 2 years [group Les]) and 51 healthy controls (group Con) underwent conventional magnetic resonance imaging (MRI) and ESWAN at 3.0 T. The mean phase value (MPV) of the OR was measured on the phase image, and thickness and signal changes of the OR were observed on the magnitude image. Results The average MPVs for the OR were 1,981.55 ± 7.75 in group Mor, 1,998.45 ± 2.01 in group Les, and 2,000.48 ± 5.53 in group Con. In group Mor, 28 patients with bilateral OR lesions showed bilateral OR thinning with a heterogeneous signal, and 14 patients with unilateral OR lesions showed ipsilateral OR thinning with a heterogeneous signal. In the remaining nine patients without OR lesions and in group Con, the bilateral OR had a normal appearance. In the patients, a negative correlation was found between DD and OR thickness and a positive correlation was found between MPV and OR thickness. Conclusions We confirmed iron deposition in the OR in the RRMS patients, and the OR thickness was lower in the patients than in the controls. Key Points • Enhanced T 2 * -weighted magnetic resonance angiography (ESWAN) provides new insights into multiple sclerosis (MS). • Focal destruction of the optic radiation (OR) is detectable by ESWAN. • Iron deposition in OR can be measured on ESWAN phase image in MS patients. • OR thickness was lower in the patients than in the controls. • Iron deposition and thickness changes of the OR are associated with disease duration.
ISSN:0938-7994
1432-1084
DOI:10.1007/s00330-018-5461-8