Changing geographical patterns and trends in cancer incidence in children and adolescents in Europe, 1991–2010 (Automated Childhood Cancer Information System): a population-based study

A deceleration in the increase in cancer incidence in children and adolescents has been reported in several national and regional studies in Europe. Based on a large database representing 1·3 billion person-years over the period 1991–2010, we provide a consolidated report on cancer incidence trends...

Full description

Saved in:

Bibliographic Details
Published in:	The lancet oncology 2018-09, Vol.19 (9), p.1159-1169
Main Authors:	Steliarova-Foucher, Eva, Fidler, Miranda M, Colombet, Murielle, Lacour, Brigitte, Kaatsch, Peter, Piñeros, Marion, Soerjomataram, Isabelle, Bray, Freddie, Coebergh, Jan Willem, Peris-Bonet, Rafael, Stiller, Charles A, Hackl, Monika, Zborovskaya, Anna, Dimitrova, Nadya, Valerianova, Zdravka, Dušek, Ladislav, Mägi, Margit, Monnereau, Alain, Clavel, Jacqueline, Velten, Michel, Guizard, Anne-Valérie, Bouvier, Véronique, Troussard, Xavier, Woronoff, Anne-Sophie, Marrer, Emilie, Trétarre, Brigitte, Colonna, Marc, Ganry, Olivier, Grosclaude, Pascale, Holleczek, Berndt, Jakab, Zsuzsanna, Tryggvadóttir, Laufey, Mangone, Lucia, Merletti, Franco, Ferretti, Stefano, Caruso, Bianca, Michiara, Maria, Tumino, Rosario, Falcini, Fabio, Zanetti, Roberto, Tagliabue, Giovanna, Visser, Otto, Ursin, Giske, Mężyk, Ryszard, Kepska, Kamila, Laranja Pontes, José, Primic Žakelj, Maja, Fernández-Delgado, Rafael, Vicente Raneda, Marisa L, Almar Marqués, Enrique, Quirós Garcia, José Ramón, Lopez de Munain, Arantza, Marcos-Gragera, Rafael, Sanchez-Perez, Maria-Jose, Ramos Monserrat, Maria, Ardanaz, Eva, Galceran, Jaume, Khan, Staffan, Kuehni, Claudia E, Bouchardy, Christine, Levi, Fabio, Konzelmann, Isabelle, Rohrmann, Sabine, Vernon, Sally, Brewster, David H, White, Ceri, Dolya, Anastasia
Format:	Article
Language:	eng
Subjects:	Adolescent Adolescents Age Age Distribution Age of Onset Automation Calendars Cancer Central nervous system Child Child, Preschool Children Codes Diagnosis Europe - epidemiology Female Health risk assessment Health Status Disparities Humans Incidence Infant Infant, Newborn Information systems Leukemia Life Sciences Lymphoma Male Morphology Neoplasms - diagnosis Neoplasms - epidemiology Population Population studies Registration Registries Risk Factors Santé publique et épidémiologie Skin cancer Studies Teenagers Temporal variations Time Factors Trends Tumors Young Adult
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	A deceleration in the increase in cancer incidence in children and adolescents has been reported in several national and regional studies in Europe. Based on a large database representing 1·3 billion person-years over the period 1991–2010, we provide a consolidated report on cancer incidence trends at ages 0–19 years. We invited all population-based cancer registries operating in European countries to participate in this population-based registry study. We requested a listing of individual records of cancer cases, including sex, age, date of birth, date of cancer diagnosis, tumour sequence number, primary site, morphology, behaviour, and the most valid basis of diagnosis. We also requested population counts in each calendar year by sex and age for the registration area, from official national sources, and specific information about the covered area and registration practices. An eligible registry could become a contributor if it provided quality data for all complete calendar years in the period 1991–2010. Incidence rates and the average annual percentage change with 95% CIs were reported for all cancers and major diagnostic groups, by region and overall, separately for children (age 0–14 years) and adolescents (age 15–19 years). We examined and quantified the stability of the trends with joinpoint analyses. For the years 1991–2010, 53 registries in 19 countries contributed a total of 180 335 unique cases. We excluded 15 162 (8·4%) of 180 335 cases due to differing practices of registration, and considered the quality indicators for the 165 173 cases included to be satisfactory. The average annual age-standardised incidence was 137·5 (95% CI 136·7–138·3) per million person-years and incidence increased significantly by 0·54% (0·44–0·65) per year in children (age 0–14 years) with no change in trend. In adolescents, the combined European incidence was 176·2 (174·4–178·0) per million person-years based on all 35 138 eligible cases and increased significantly by 0·96% (0·73–1·19) per year, although recent changes in rates among adolescents suggest a deceleration in this increasing trend. We observed temporal variations in trends by age group, geographical region, and diagnostic group. The combined age-standardised incidence of leukaemia based on 48 458 cases in children was 46·9 (46·5–47·3) per million person-years and increased significantly by 0·66% (0·48–0·84) per year. The average overall incidence of leukaemia in adolescents was 23·6 (22·9–24·3) per milli
ISSN:	1470-2045 1474-5488