Treatment of severe periodontic-endodontic combined lesions with minocycline hydrochloride ointment combined with mineral trioxide aggregate

Periodontic-endodontic combined lesions affect the quality of life of patients. The present study aimed to explore a way to achieve maximal effect in treating periodontic-endodontic combined lesions by using a combination of minocycline hydrochloride ointment (MHO) and mineral trioxide aggregate (MT...

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Bibliographic Details
Published in:Experimental and therapeutic medicine 2018-08, Vol.16 (2), p.1389-1396
Main Authors: Shao, Wen, Xiao, Feng, Xu, Zhong-Xin, Ren, Rui-Han, Wang, Yong, Wu, Yi-Qun
Format: Article
Language:English
Subjects:
Analysis
Antibiotics
Combination drug therapy
Cytotoxicity
Disease
Dosage and administration
Infections
Minocycline
Periodontics
Researchers
Teeth
Treatment outcome
Vitamin deficiency
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Summary:Periodontic-endodontic combined lesions affect the quality of life of patients. The present study aimed to explore a way to achieve maximal effect in treating periodontic-endodontic combined lesions by using a combination of minocycline hydrochloride ointment (MHO) and mineral trioxide aggregate (MTA). In the present study, 294 patients were randomly divided into four groups: Control group, MHO group, MTA group and combination group. Endodontic and periodontic therapy was applied simultaneously on the anterior and posterior teeth of patients, and patient characteristics, gingival index (GI) and probing depth (PD) were noted when the patients were treated with the different strategies. Reexamination was performed 4 weeks after treatment and follow-up was performed 2 years later. The present study demonstrated that medical history, root filling and periapical condition within the patients were deemed as key factors in determining the success of treatment of periodontic-endodontic combined lesions. The effect of the combination treatment significantly exceeded that of either treatment alone (P
ISSN:1792-0981
1792-1015
DOI:10.3892/etm.2018.6341