Plastic change of prefrontal cortex mediates anxiety-like behaviors associated with chronic pain in neuropathic rats

Clinical studies show that anxiety and chronic pain are concomitant. The neural basis for the comorbidity is unclear. The prefrontal cortex (PFC) has been recognized as a critical area for affective disorders and chronic pain modulation. In this study, we examined the role of the PFC in the pathogen...

Full description

Saved in:
Bibliographic Details
Published in:Molecular pain 2018-01, Vol.14, p.1744806918783931-1744806918783931
Main Authors: Sang, Kangning, Bao, Chaofei, Xin, Yushi, Hu, Shunan, Gao, Xian, Wang, Yongsheng, Bodner, Mark, Zhou, Yong-Di, Dong, Xiao-Wei
Format: Article
Language:English
Subjects:
Affective disorders
Anxiety
Chronic pain
Citalopram
Hippocampus
Motor activity
Neural plasticity
Neuralgia
Open-field behavior
Pain
Prefrontal cortex
Serotonin
Serotonin transporter
Synchronization
Theta rhythms
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Clinical studies show that anxiety and chronic pain are concomitant. The neural basis for the comorbidity is unclear. The prefrontal cortex (PFC) has been recognized as a critical area for affective disorders and chronic pain modulation. In this study, we examined the role of the PFC in the pathogenesis of anxiety associated with chronic pain in a rat model of neuropathic pain with spare nerve injury (SNI). The SNI rats showed apparent anxiety-like behaviors in both open field (OF) test and elevated-plus maze (EPM) test eight weeks after surgery. Thus, the number of entries to the central area in the OF decreased to 45% (±5%, n = 15) of sham control (n = 17), while the overall motor activity (i.e., total distance) was unaffected. In the EPM, the percentage of entries into the open arms significantly (p 
ISSN:1744-8069
1744-8069
DOI:10.1177/1744806918783931