Differences in swallow physiology in patients with left and right hemispheric strokes

We sought to determine the impact of lesion lateralization and lesion volume on swallow impairment on group-level by comparing patients with left and right hemisphere strokes and on patient-level by analyzing patients individually. We performed a retrospective, observational, cross-sectional study o...

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Bibliographic Details
Published in:Physiology & behavior 2018-10, Vol.194, p.144-152
Main Authors: Wilmskoetter, Janina, Martin-Harris, Bonnie, Pearson, William G., Bonilha, Leonardo, Elm, Jordan J., Horn, Janet, Bonilha, Heather S.
Format: Article
Language:English
Subjects:
Cerebral hemispheres
Deglutition
Deglutition disorders
Stroke
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Summary:We sought to determine the impact of lesion lateralization and lesion volume on swallow impairment on group-level by comparing patients with left and right hemisphere strokes and on patient-level by analyzing patients individually. We performed a retrospective, observational, cross-sectional study of 46 patients with unilateral (22 left, 24 right), acute, first-ever, ischemic strokes who received a diffusion weighted MRI (DW-MRI) and modified barium swallow study (MBSS) during their acute hospital stay. We determined lesion side on the DW-MRI and measured swallow physiology using the Modified Barium Swallow Impairment Profile (MBSImP™©), Penetration-Aspiration Scale (PAS), swallow timing, distance, area, and speed measures. We performed Pearson's Chi-Square and Wilcoxon Rank-Sum tests to compare patients with left and right hemisphere strokes, and Pearson or Spearman correlation, simple logistic regression, linear, and logistic multivariable regression modeling to assess the relationship between variables. At the group-level, there were no differences in MBSImP oral swallow impairment scores between patients with left and right hemisphere stroke. In adjusted analyses, patients with right hemisphere strokes showed significantly worse MBSImP pharyngeal total scores (p = 0.02), worse MBSImP component specific scores for laryngeal vestibular closure (Bonferroni adjusted alpha p ≤ 0.0029), and worse PAS scores (p = 0.03). Patients with right hemisphere strokes showed worse timing, distance, area, and speed measures. Lesion volume was significantly associated with MBSImP pharyngeal residue (p = 0.03) and pharyngeal total scores (p = 0.04). At the patient-level, 24% of patients (4 left, 7 right) showed opposite patterns of MBSImP oral and pharyngeal swallow impairment than seen at group-level. Our study showed differences in swallow physiology between patients with right and left unilateral strokes with patients with right hemisphere strokes showing worse pharyngeal impairment. Lesion lateralization seems to be a valuable marker for the severity of swallowing impairment at the group-level but less informative at the patient-level. •Both left and right unilateral strokes may lead to oropharyngeal swallow impairment.•Patients with right compared to left unilateral strokes had greater pharyngeal impairment.•Patients with right unilateral strokes had decreased hyo-laryngeal impairment.•Patients with right unilateral strokes had higher risks for aspiration and residue
ISSN:0031-9384
1873-507X
DOI:10.1016/j.physbeh.2018.05.010