Mamu-B17 + Rhesus Macaques Vaccinated with env , vif , and nef Manifest Early Control of SIVmac239 Replication

Certain major histocompatibility complex class I (MHC-I) alleles are associated with spontaneous control of viral replication in human immunodeficiency virus (HIV)-infected people and simian immunodeficiency virus (SIV)-infected rhesus macaques (RMs). These cases of "elite" control of HIV/...

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Bibliographic Details
Published in:Journal of virology 2018-08, Vol.92 (16)
Main Authors: Martins, Mauricio A, Tully, Damien C, Pedreño-Lopez, Núria, von Bredow, Benjamin, Pauthner, Matthias G, Shin, Young C, Yuan, Maoli, Lima, Noemia S, Bean, David J, Gonzalez-Nieto, Lucas, Domingues, Aline, Gutman, Martin J, Maxwell, Helen S, Magnani, Diogo M, Ricciardi, Michael J, Bailey, Varian K, Altman, John D, Burton, Dennis R, Ejima, Keisuke, Allison, David B, Evans, David T, Rakasz, Eva G, Parks, Christopher L, Bonaldo, Myrna C, Capuano, 3rd, Saverio, Lifson, Jeffrey D, Desrosiers, Ronald C, Allen, Todd M, Watkins, David I
Format: Article
Language:English
Subjects:
Alleles
Animals
Antibodies, Neutralizing - blood
Antibodies, Viral - blood
Gene Products, env - immunology
Gene Products, nef - immunology
Gene Products, vif - immunology
Histocompatibility Antigens Class I - genetics
Macaca mulatta
SAIDS Vaccines - administration & dosage
SAIDS Vaccines - immunology
Simian Acquired Immunodeficiency Syndrome - immunology
Simian Acquired Immunodeficiency Syndrome - prevention & control
Simian Acquired Immunodeficiency Syndrome - virology
Simian Immunodeficiency Virus - immunology
Simian Immunodeficiency Virus - physiology
Vaccines and Antiviral Agents
Viral Load
Viremia - prevention & control
Virus Replication
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Summary:Certain major histocompatibility complex class I (MHC-I) alleles are associated with spontaneous control of viral replication in human immunodeficiency virus (HIV)-infected people and simian immunodeficiency virus (SIV)-infected rhesus macaques (RMs). These cases of "elite" control of HIV/SIV replication are often immune-mediated, thereby providing a framework for studying anti-lentiviral immunity. In this study, we examined how vaccination impacts SIV replication in RMs expressing the MHC-I allele Approximately 21% of and 50% of RMs control chronic-phase viremia after SIVmac239 infection. Because CD8 T cells targeting Mamu-B*08-restricted SIV epitopes have been implicated in virologic suppression in RMs, we investigated whether this might also be true for RMs. Two groups of RMs were vaccinated with genes encoding Mamu-B*17-restricted epitopes in Vif and Nef. These genes were delivered by themselves (group 1) or together with (group 2). Group 3 included MHC-I-matched RMs and served as the control group. Surprisingly, the group 1 vaccine regimen had little effect on viral replication compared to group 3, suggesting that unlike RMs, preexisting SIV-specific CD8 T cells alone do not facilitate long-term virologic suppression in RMs. Remarkably, however, 5/8 group 2 vaccinees controlled viremia to
ISSN:0022-538X
1098-5514
1098-5514
DOI:10.1128/JVI.00690-18