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Prolactin as immune cell regulator in Toxocara canis somatic larvae chronic infection
Toxocariasis is a zoonotic disease produced by ingestion of larval spp. eggs. Prolactin (PRL) has been considered to have an important role in infection. Recent evidence has found that PRL directly can increase parasite growth and differentiation of The present study, evaluated the effect of high PR...
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Published in: | Bioscience reports 2018-08, Vol.38 (4) |
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Main Authors: | , , , , , , , , |
Format: | Article |
Language: | English |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Toxocariasis is a zoonotic disease produced by ingestion of larval
spp. eggs. Prolactin (PRL) has been considered to have an important role in
infection. Recent evidence has found that PRL directly can increase parasite growth and differentiation of
The present study, evaluated the effect of high PRL levels on the immune system's response and parasites clearance in chronic infection. Our results showed that hyperprolactinemia did not affect the number of larvae recovered from several tissues in rats. Parasite-specific antibody production, showed no difference between the groups. Lung tissue presented eosinophilic granulomas typical of a chronic infection in all the experimental groups. Flow cytometry analysis was made in order to determine changes in the percentage of innate and adaptive immune cell subpopulations in the spleen, peripheric (PLN) and mesenteric (MLN) lymphatic nodes. The results showed a differential effect of PRL and infection on different immune compartments in the percent of total T cells, T helper cells, T cytotoxic cells, B cells, NK cells, and Tγδ cells. To our knowledge, for the first time it is demonstrated that PRL can have an immunomodulatory role during
chronic infection in the murine host. |
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ISSN: | 0144-8463 1573-4935 |
DOI: | 10.1042/BSR20180305 |