Soy protein supplementation is not androgenic or estrogenic in college-aged men when combined with resistance exercise training

It is currently unclear as to whether sex hormones are significantly affected by soy or whey protein consumption. Additionally, estrogenic signaling may be potentiated via soy protein supplementation due to the presence of phytoestrogenic isoflavones. Limited also evidence suggests that whey protein...

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Bibliographic Details
Published in:Scientific reports 2018-07, Vol.8 (1), p.11151-13, Article 11151
Main Authors: Haun, Cody T, Mobley, C Brooks, Vann, Christopher G, Romero, Matthew A, Roberson, Paul A, Mumford, Petey W, Kephart, Wesley C, Healy, James C, Patel, Romil K, Osburn, Shelby C, Beck, Darren T, Arnold, Robert D, Nie, Ben, Lockwood, Christopher M, Roberts, Michael D
Format: Article
Language:English
Subjects:
17β-Estradiol
Adipose tissue
Androgen receptors
Androgens
Gene expression
Hormones
Isoflavones
Lipase
mRNA
Ornithine
Ornithine decarboxylase
Proteins
Sex hormones
Soy products
Supplements
Testosterone
Whey protein
Xenoestrogens
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Summary:It is currently unclear as to whether sex hormones are significantly affected by soy or whey protein consumption. Additionally, estrogenic signaling may be potentiated via soy protein supplementation due to the presence of phytoestrogenic isoflavones. Limited also evidence suggests that whey protein supplementation may increase androgenic signaling. Therefore, the purpose of this study was to examine the effects of soy protein concentrate (SPC), whey protein concentrate (WPC), or placebo (PLA) supplementation on serum sex hormones, androgen signaling markers in muscle tissue, and estrogen signaling markers in subcutaneous (SQ) adipose tissue of previously untrained, college-aged men (n = 47, 20 ± 1 yrs) that resistance trained for 12 weeks. Fasting serum total testosterone increased pre- to post-training, but more so in subjects consuming WPC (p 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-018-29591-4