Sulfatase-1 knockdown promotes in vitro and in vivo aggressive behavior of murine hepatocarcinoma Hca-P cells through up-regulation of mesothelin

Our previous study (Oncotarget 2016; 7:46) demonstrated that the over-expression of sulfatase-1 in murine hepatocarcinoma Hca-F cell line (a murine HCC cell with lymph node metastatic [LNM] rate of >75%) downregulates mesothelin and leads to reduction in lymphatic metastasis, both in vitro and in...

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Bibliographic Details
Published in:Journal of cell communication and signaling 2018-09, Vol.12 (3), p.603-613
Main Authors: Mahmoud, Salma Abdi, Ibrahim, Mohammed Mohammed, Musa, Ahmed Hago, Huang, Yuhong, Zhang, Jun, Wang, Jingwen, Wei, Yuanyi, Wang, Li, Zhou, Shunting, Xin, Boyi, Xuan, Wei, Tang, Jianwu
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedicine
Cell Biology
Cell growth
Cell migration
Cell proliferation
Hepatocellular carcinoma
Kinases
Life Sciences
Liver cancer
Lymph node metastasis
Lymph nodes
Mesothelin
Metastases
Metastasis
Migration and invasion
Overexpression
Research Article
Sulfatase‐1
Up-regulation
Western blotting
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Summary:Our previous study (Oncotarget 2016; 7:46) demonstrated that the over-expression of sulfatase-1 in murine hepatocarcinoma Hca-F cell line (a murine HCC cell with lymph node metastatic [LNM] rate of >75%) downregulates mesothelin and leads to reduction in lymphatic metastasis, both in vitro and in vivo. In current work, we investigated the effects of Sulf-1 knockdown on mesothelin (Msln) and it’s effects on the in vitro cell proliferation, migration, invasion, and in vivo tumor growth and LNM rate for Hca-P cells (a murine HCC cell with LNM rate of
ISSN:1873-9601
1873-961X
DOI:10.1007/s12079-017-0411-9