Failed Recovery of Glycemic Control and Myofibrillar Protein Synthesis With 2 wk of Physical Inactivity in Overweight, Prediabetic Older Adults

Physical inactivity impairs insulin sensitivity, which is exacerbated with aging. We examined the impact of 2 wk of acute inactivity and recovery on glycemic control, and integrated rates of muscle protein synthesis in older men and women. Twenty-two overweight, prediabetic older adults (12 men, 10...

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Published in:	The journals of gerontology. Series A, Biological sciences and medical sciences Biological sciences and medical sciences, 2018-07, Vol.73 (8), p.1070-1077
Main Authors:	McGlory, Chris, von Allmen, Mark T, Stokes, Tanner, Morton, Robert W, Hector, Amy J, Lago, Briony A, Raphenya, Amogelang R, Smith, Brennan K, McArthur, Andrew G, Steinberg, Gregory R, Baker, Steven K, Phillips, Stuart M
Format:	Article
Language:	eng
Subjects:	Biochemistry Body weight Gerontology Protein biosynthesis Protein expression Protein synthesis Proteomics The Journal of Gerontology: Medical Sciences
Online Access:	Get full text
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Summary:	Physical inactivity impairs insulin sensitivity, which is exacerbated with aging. We examined the impact of 2 wk of acute inactivity and recovery on glycemic control, and integrated rates of muscle protein synthesis in older men and women. Twenty-two overweight, prediabetic older adults (12 men, 10 women, 69 ± 4 y) undertook 7 d of habitual activity (baseline; BL), step reduction (SR;
ISSN:	1079-5006 1758-535X