Subthalamic nucleus deep brain stimulation evokes resonant neural activity

Deep brain stimulation (DBS) is a rapidly expanding treatment for neurological and psychiatric conditions; however, a target‐specific biomarker is required to optimize therapy. Here, we show that DBS evokes a large‐amplitude resonant neural response focally in the subthalamic nucleus. This response...

Full description

Saved in:
Bibliographic Details
Published in:Annals of neurology 2018-05, Vol.83 (5), p.1027-1031
Main Authors: Sinclair, Nicholas C., McDermott, Hugh J., Bulluss, Kristian J., Fallon, James B., Perera, Thushara, Xu, San San, Brown, Peter, Thevathasan, Wesley
Format: Article
Language:English
Subjects:
Anesthesia
Biomarkers
Brain
Deep brain stimulation
Deep Brain Stimulation - methods
Electrical stimuli
Electrodes, Implanted
Female
Humans
Implantation
Male
Middle Aged
Movement disorders
Neurodegenerative diseases
Nuclei
Optimization
Parkinson Disease - physiopathology
Parkinson Disease - therapy
Parkinson's disease
Placebo effect
Stimulation
Subthalamic nucleus
Subthalamic Nucleus - physiopathology
Subthalamic Nucleus - surgery
Surgery
Therapy
Treatment Outcome
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Deep brain stimulation (DBS) is a rapidly expanding treatment for neurological and psychiatric conditions; however, a target‐specific biomarker is required to optimize therapy. Here, we show that DBS evokes a large‐amplitude resonant neural response focally in the subthalamic nucleus. This response is greatest in the dorsal region (the clinically optimal stimulation target for Parkinson disease), coincides with improved clinical performance, is chronically recordable, and is present under general anesthesia. These features make it a readily utilizable electrophysiological signal that could potentially be used for guiding electrode implantation surgery and tailoring DBS therapy to improve patient outcomes. Ann Neurol 2018;83:1027–1031
ISSN:0364-5134
1531-8249
DOI:10.1002/ana.25234