Relative contributions of lean and fat mass to bone strength in young Hispanic and non-Hispanic girls

With the high prevalence of childhood obesity, especially among Hispanic children, understanding how body weight and its components of lean and fat mass affect bone development is important, given that the amount of bone mineral accrued during childhood can determine osteoporosis risk later in life....

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Published in:Bone (New York, N.Y.) N.Y.), 2018-08, Vol.113, p.144-150
Main Authors: Hetherington-Rauth, Megan, Bea, Jennifer W., Blew, Robert M., Funk, Janet L., Hingle, Melanie D., Lee, Vinson R., Roe, Denise J., Wheeler, Mark D., Lohman, Timothy G., Going, Scott B.
Format: Article
Language:English
Subjects:
Absorptiometry, Photon
Biomechanical Phenomena
Body Composition - physiology
Bone and Bones - physiology
Bone Density - physiology
Bone strength
Child
Fat mass
Female
Girls
Hispanic
Hispanic Americans
Humans
Lean mass
Peripheral quantitative computed tomography (pQCT)
Tomography, X-Ray Computed
Weight-Bearing - physiology
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Summary:With the high prevalence of childhood obesity, especially among Hispanic children, understanding how body weight and its components of lean and fat mass affect bone development is important, given that the amount of bone mineral accrued during childhood can determine osteoporosis risk later in life. The aim of this study was to assess the independent contributions of lean and fat mass on volumetric bone mineral density (vBMD), geometry, and strength in both weight-bearing and non-weight-bearing bones of Hispanic and non-Hispanic girls. Bone vBMD, geometry, and strength were assessed at the 20% distal femur, the 4% and 66% distal tibia, and the 66% distal radius of the non-dominant limb of 326, 9- to 12-year-old girls using peripheral quantitative computed tomography (pQCT). Total body lean and fat mass were measured by dual-energy x-ray absorptiometry (DXA). Multiple linear regression was used to assess the independent relationships of fat and lean mass with pQCT bone measures while adjusting for relevant confounders. Potential interactions between ethnicity and both fat and lean mass were also tested. Lean mass was a significant positive contributor to all bone outcomes (p 
ISSN:8756-3282
1873-2763
DOI:10.1016/j.bone.2018.05.023