Skeletal Muscle Function in the Oldest-Old: The Role of Intrinsic and Extrinsic Factors

Although skeletal muscle function is diminished with advanced age, single muscle fiber function seems to be preserved. Therefore, this review examines the hypothesis that the skeletal muscle fiber, per se, is not the predominant factor responsible for the reduction in force-generating capacity in th...

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Bibliographic Details
Published in:Exercise and sport sciences reviews 2018-07, Vol.46 (3), p.188-194
Main Authors: Venturelli, Massimo, Reggiani, Carlo, Richardson, Russell S, Schena, Federico
Format: Article
Language:English
Subjects:
Aged, 80 and over
Aging - physiology
Humans
Motor Neurons - physiology
Muscle Contraction
Muscle Strength
Muscle, Skeletal - physiology
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Summary:Although skeletal muscle function is diminished with advanced age, single muscle fiber function seems to be preserved. Therefore, this review examines the hypothesis that the skeletal muscle fiber, per se, is not the predominant factor responsible for the reduction in force-generating capacity in the oldest-old, but, rather, is attributable to a combination of factors external to the muscle fibers.
ISSN:0091-6331
1538-3008
DOI:10.1249/jes.0000000000000155