Recurrent coronary disease in HIV‐infected patients: role of drug–drug interactions

Cardiovascular disease represents a leading comorbidity in HIV populations. Different factors may contribute to the recurrence of cardiovascular events in HIV‐infected patients. Here, we describe two patients with HIV infection and an acute coronary syndrome who developed in‐stent thrombosis after a...

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Bibliographic Details
Published in:British journal of clinical pharmacology 2018-07, Vol.84 (7), p.1617-1619
Main Authors: Bravo, Iria, Álvarez, Hortensia, Mariño, Ana, Clotet, Bonaventura, Moltó, José
Format: Article
Language:English
Subjects:
Adult
Anti-HIV Agents - pharmacology
Anti-HIV Agents - therapeutic use
Case Report
Case Reports
Coronary Artery Disease - therapy
coronary disease
Cytochrome P-450 CYP3A - metabolism
Cytochrome P-450 CYP3A Inducers - pharmacology
Cytochrome P-450 CYP3A Inducers - therapeutic use
Drug Interactions
HIV infection
HIV Infections - drug therapy
Humans
Male
Middle Aged
Percutaneous Coronary Intervention - instrumentation
Percutaneous Coronary Intervention - methods
Platelet Aggregation Inhibitors - pharmacology
Platelet Aggregation Inhibitors - therapeutic use
Recurrence
Risk Factors
Stents
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Summary:Cardiovascular disease represents a leading comorbidity in HIV populations. Different factors may contribute to the recurrence of cardiovascular events in HIV‐infected patients. Here, we describe two patients with HIV infection and an acute coronary syndrome who developed in‐stent thrombosis after a percutaneous revascularization procedure. Also, we discuss the potential role of drug interactions between antiretroviral and antiplatelet treatments as a contributing factor for recurrent coronary disease in HIV‐infected patients.
ISSN:0306-5251
1365-2125
DOI:10.1111/bcp.13583